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Prevention of clinically important deteriorations in COPD with umeclidinium/vilanterol

Authors Singh D, Maleki-Yazdi MR, Tombs L, Iqbal A, Fahy WA, Naya I

Received 1 December 2015

Accepted for publication 19 February 2016

Published 24 June 2016 Volume 2016:11(1) Pages 1413—1424

DOI https://doi.org/10.2147/COPD.S101612

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Richard Russell



Dave Singh,1 M Reza Maleki-Yazdi,2 Lee Tombs,3 Ahmar Iqbal,4 William A Fahy,5 Ian Naya5

1Medicines Evaluation Unit, University of Manchester, University Hospital of South Manchester NHS Foundation Trust, Manchester, UK; 2Division of Respiratory Medicine, Women’s College Hospital, University of Toronto, ON, Canada; 3Precise Approach LTD, London UK; 4Respiratory Medical Franchise, GSK, Research Triangle Park, NC, USA; 5Respiratory Medicines Development Centre, GSK, Stockley Park, Middlesex, UK

Background: Minimizing the risk of disease progression and exacerbations is the key goal of COPD management, as these are well-established indicators of poor COPD prognosis. We developed a novel composite end point assessing three important aspects (lung function, health status, and exacerbations) of worsening in COPD. The objective was to determine whether dual bronchodilation with umeclidinium/vilanterol (UMEC/VI) reduces clinically important deteriorations (CIDs) in COPD versus placebo or bronchodilator monotherapy. 
Methods: This study is a post hoc analysis of two 24-week trials comparing UMEC/VI 62.5/25 µg with UMEC 62.5 µg, VI 25 µg, or placebo (Study A; NCT01313650), or UMEC/VI 62.5/25 µg with tiotropium (TIO) 18 µg (Study B; NCT01777334) in patients with symptomatic COPD, without a history of frequent exacerbations. Deterioration was assessed as the time to a first CID, a composite measure defined as a decrease of ≥100 mL in trough forced expiratory volume in 1 second or ≥4-unit increase in St George’s Respiratory Questionnaire total score or an on-treatment moderate-to-severe COPD exacerbation. 
Results: In Study A, fewer patients experienced a first CID with UMEC/VI (44%) versus UMEC (50%), VI (56%), and placebo (75%). The risk of a first CID was reduced with UMEC/VI (hazard ratio [HR]: 0.37 [95% confidence interval, CI: 0.30, 0.45]), UMEC (HR: 0.46 [95% CI: 0.38, 0.56]), and VI (HR: 0.55 [95% CI: 0.45, 0.66]; all P<0.001) versus placebo, and with UMEC/VI versus UMEC (HR: 0.80 [95% CI: 0.65, 0.97]; P<0.05) and versus VI (HR: 0.67 [95% CI: 0.55, 0.81]; P<0.001). In Study B, fewer patients experienced a first CID with UMEC/VI (41%) versus TIO (59%). UMEC/VI reduced the risk of a first composite CID by 43% versus TIO (HR: 0.57 [95% CI: 0.47, 0.69]; P<0.001). 
Conclusion: This exploratory analysis, using a new assessment of clinical deterioration in COPD, revealed that a majority of symptomatic patients with low exacerbation risk experienced a deterioration during the 24-week study periods. UMEC/VI reduces the risk of a first CID versus placebo or bronchodilator monotherapy.

Keywords: COPD, deterioration, airway stability, UMEC/VI

Introduction

The management goals of COPD emphasize the need to reduce symptoms, improve health status, increase exercise tolerance, prevent exacerbations, slow disease progression, and reduce mortality.1 In patients with moderate-to-severe COPD without a history of frequent exacerbations, bronchodilator monotherapy with long-acting muscarinic antagonist (LAMA) is recommended.1 However, most patients receiving long-acting bronchodilator monotherapy still report moderate-to-severe breathlessness and regular rescue medication use.2 Consequently, maintenance therapy with fixed-dose combinations of LAMA and long-acting-β2-agonist (LABA) is an alternative treatment option for patients with high symptom burden.3

The combination of the LAMA, umeclidinium (UMEC), and the LABA, vilanterol (VI), provides significant and clinically relevant improvements in lung function, dyspnea, and health status compared with placebo in patients with COPD.4,5 UMEC/VI treatment has also demonstrated greater improvements in lung function and patient-reported outcomes (PROs) compared with the LAMA tiotropium (TIO).4,6 Similar improvements in lung function and PROs, and similar safety profiles have been reported for other LAMA/LABA combinations compared with long-acting bronchodilator monotherapy.7

Studies comparing bronchodilator combinations with their monotherapy components have not consistently demonstrated statistically significant improvements in PROs.810 Furthermore, the magnitude of PRO changes has been below the accepted threshold for the minimal clinically important difference (MCID).11 However, MCID values have traditionally been used for comparisons with placebo, and as such, the magnitude of improvement possible when comparing active treatments is likely to be smaller than the MCID.

Clinical trials of bronchodilators in COPD normally focus on using MCIDs to determine improvements in lung function and PROs. However, it is also important to understand whether these treatments improve airway stability and prevent disease worsening, such as exacerbations. Exacerbations and rapid deteriorations in lung function are well-established indicators of poor long-term COPD prognosis.1217 Furthermore, deteriorations in health status, measured by a St George’s Respiratory Questionnaire (SGRQ) score greater than the MCID11 over 1 year, increase the prospective risk of hospitalizations and mortality during the 2 subsequent years.18 Therefore, we have developed an exploratory composite end point (clinically important deterioration [CID]) to assess individual deteriorations in lung function and health status (defined by the accepted MCIDs) as well as the incidence of moderate-to-severe COPD exacerbations.11,19,20

Using data obtained from the two largest randomized, controlled, 6-month trials comparing UMEC/VI with placebo, the UMEC/VI bronchodilator monotherapy components (UMEC and VI), or TIO in symptomatic patients with moderate-to-very severe COPD, this post hoc analysis assessed whether a fixed-dose combination of UMEC/VI prolonged the time patients remained free of a CID compared with placebo or long-acting bronchodilator monotherapies.

Materials and methods

Study design

This study used data from two independent retrospective, post hoc analyses of two 24-week, Phase III, multicenter, randomized, double-blind, parallel-group studies. In Study A (DB2113373; NCT01313650), patients were randomized (3:3:3:2) to UMEC/VI 62.5/25 μg (delivering 55/22 μg; GSK, Brentford, UK), UMEC 62.5 μg (delivering 55 μg), VI 25 μg (delivering 22 μg), or placebo, all delivered via the ELLIPTA™ dry powder inhaler (GSK).4 In Study B (ZEP117115; NCT01777334),6 patients were randomized (1:1) to receive once-daily UMEC/VI 62.5/25 μg inhaled via the ELLIPTA™ dry powder inhaler or TIO 18 μg inhaled via the HandiHaler® (Boehringer Ingelheim, Ingelheim, Germany).6 Detailed methodologies for both studies have been previously published.4,6 Both studies included in this post hoc analysis were approved by the Chesapeake Institutional Review Board (Columbia, Maryland, USA), as well as each relevant national, regional, or independent ethics committee or institutional review board and conducted in accordance with the Declaration of Helsinki and Good Clinical Practice guidelines.

Key inclusion criteria for both studies included age ≥40 years with a diagnosis of COPD according to the American Thoracic Society/European Respiratory Society guidelines,21 a forced expiratory volume in 1 second (FEV1)/forced vital capacity ratio of <0.70 and a post-salbutamol FEV1 ≤70% of predicted normal, and a modified Medical Research Council Dyspnea Scale score ≥2. Key exclusion criteria included a diagnosis of asthma or other respiratory conditions, hospitalization for COPD or pneumonia within the 12 weeks before visit 1, and the use of prohibited medications. The primary study end point in both studies was trough FEV1 on day 169. SGRQ score on day 168 was also determined.

Methods

The primary end point of this exploratory analysis was the time to a first CID, a composite measure defined as 1) a decrease of ≥100 mL from baseline in trough FEV1,19,20 2) a deterioration in health-related quality of life defined as ≥4-unit increase from baseline in SGRQ total score,11 or 3) the occurrence of an on-treatment moderate-to-severe COPD exacerbation (defined as an acute worsening of COPD symptoms requiring the use of additional treatment including oral corticosteroids, antibiotics, emergency department treatment, or hospitalization). Deteriorations in trough FEV1 from baseline were determined using data from seven trial visits post-randomization (days 2, 28, 56, 84, 112, 168, and 169) and SGRQ total score from three study visits (days 28, 84, and 168). Time to first deterioration in each of the components of the composite CID was also assessed. Time to a first sustained composite CID was also determined and defined as a CID occurring on two or more consecutive visits 4 weeks apart or for ≥50% of all available subsequent visits. For sustained trough FEV1 decreases, the time between days 168 and 169 was not considered a separate visit; a decrease of ≥100 mL in trough FEV1 before day 168 was considered a sustained decrease if it was maintained at either day 168 or day 169. As protocols from both studies required patients be withdrawn from the study following a moderate-to-severe COPD exacerbation, the first incidence of an exacerbation was documented as a sustained CID. Safety assessment in both studies included the monitoring of adverse events (AEs).

Statistical analyses

Analyses were performed on the intent-to-treat population, defined as all patients randomized to treatment and who received one or more doses of study medication. A sensitivity analysis was performed on data from Study B, excluding trough FEV1 data at days 2, 56, 112, and 169. Subgroup analyses were performed by COPD severity (Global Initiative for Chronic Obstructive Lung Disease [GOLD] groups B and D) and inhaled corticosteroid (ICS) use at screening (yes/no). All available data were included in the analyses, and no imputations for missing data were performed.

Statistical comparisons were completed for UMEC/VI versus UMEC, VI, or placebo, UMEC or VI versus placebo, and UMEC/VI versus TIO. Hazard ratios (HRs) and confidence intervals (CIs) were derived using a Cox proportional hazards model with covariates of treatment, smoking status at screening, and geographical region.

Results

Study populations

The intent-to-treat populations included 1,532 (Study A) and 905 patients (Study B). Patient demographics and baseline characteristics were similar across treatment groups (Table 1).

Table 1 Summary of patient demographics and baseline characteristics (ITT population)
Notes: Values are reported as mean (SD) unless otherwise stated. aReclassified: subject reclassified as current smoker if smoked within 6 months. bSmoking pack-years = (number of cigarettes smoked per day/20) × number of years smoked. cReversibility was defined as an increase in FEV1 of ≥12% and ≥200 mL following administration of salbutamol. dGOLD group data were not available for one patient in each of the UMEC/VI, UMEC, and VI groups. eICS use was defined as those subjects who were currently taking ICS medications at the screening visit. fDuring the 12 months prior to screening. gExacerbation requiring corticosteroid and/or antibiotic without hospitalization. hExacerbation requiring hospitalization.
Abbreviations: FEV1, forced expiratory volume in 1 second; GOLD, Global Initiative for Chronic Obstructive Lung Disease; ICS, inhaled corticosteroid; ITT, intent-to-treat; SD, standard deviation; SGRQ, St George’s Respiratory Questionnaire; TIO, tiotropium; UMEC, umeclidinium; VI, vilanterol.

Efficacy

Change in trough FEV1 and SGRQ total score

Significant improvements in trough FEV1 and SGRQ total score at the final clinical visit for Studies A and B were demonstrated with UMEC/VI, UMEC and VI versus placebo in Study A, and UMEC/VI versus TIO in Study B; results are shown in Tables S1 and S2, respectively.

Time to first composite CID in Study A

The incidence of a first composite CID ranged from 44% (UMEC/VI) to 75% (placebo) (Table 2; Figure 1A). Compared with placebo, the risk of a first composite CID was statistically significantly reduced by 63% with UMEC/VI (HR: 0.37 [95% CI: 0.30, 0.45]), 54% with UMEC (HR: 0.46 [95% CI: 0.38, 0.56]), and 45% with VI (HR: 0.55 [95% CI: 0.45, 0.66]; all P<0.001) (Table 2; Figure 2A). Significant reductions in risk with UMEC/VI versus placebo and UMEC versus placebo were observed for clinical deteriorations of all three individual parameters (P<0.05) (Table 2). The risk of clinical deteriorations in trough FEV1 and SGRQ total score was statistically significantly decreased with VI versus placebo (P<0.01) (Table 2).

Table 2 Summary and analysis of first and sustained CID in study A
Notes: *P<0.05. **P<0.01. ***P<0.001. aDefined as an acute worsening of COPD symptoms requiring the use of additional treatment including oral corticosteroids, antibiotics, emergency department treatment, or hospitalization. bAny first exacerbation was also considered a sustained deterioration as patients were withdrawn by protocol following a first event.
Abbreviations: CI, confidence interval; CID, clinically important deterioration; FEV1, forced expiratory volume in 1 second; HR, hazard ratio; ITT, intent-to-treat; SGRQ, St George’s Respiratory Questionnaire; UMEC, umeclidinium; VI, vilanterol.

Figure 1 Proportion of patients with a first and sustained CID (ITT population).
Notes: A moderate-to-severe exacerbation is defined as an acute worsening of COPD symptoms requiring the use of additional treatment including oral corticosteroids, antibiotics, emergency department treatment, or hospitalization.
Abbreviations: CID, clinically important deterioration; FEV1, forced expiratory volume in 1 second; ITT, intent-to-treat; SGRQ, St George’s Respiratory Questionnaire; TIO, tiotropium; UMEC, umeclidinium; VI, vilanterol.

Figure 2 Time to first and sustained CID (ITT population).
Notes: P-values represent comparisons between placebo and UMEC/VI, or UMEC or VI (Study A), or UMEC/VI and TIO (Study B).
Abbreviations: CID, clinically important deterioration; ITT, intent-to-treat; TIO, tiotropium; UMEC, umeclidinium; VI, vilanterol.

The risk of a first composite CID was statistically significantly reduced with UMEC/VI by 20% versus UMEC (HR: 0.80 [95% CI: 0.65, 0.97]; P<0.05) and by 33% versus VI (HR: 0.67 [95% CI: 0.55, 0.81]; P<0.001) (Table 2). The risk of deteriorations in trough FEV1 was statistically significantly reduced with UMEC/VI versus UMEC and VI (Table 2).

Time to first composite CID in Study B

The incidence of a first composite CID was 41% with UMEC/VI treatment and 59% with TIO (Table 3; Figure 1B). UMEC/VI produced a statistically significant reduction of 43% in the risk of a first composite CID versus TIO (HR: 0.57 [95% CI: 0.47, 0.69]; P<0.001) (Table 3; Figure 2B). Statistically significant reductions in risk versus TIO were observed for first deteriorations in all three individual parameters (P<0.05) (Table 3).

Table 3 Summary and analysis of first and sustained CID in Study B (ITT population)
Notes: *P<0.05. ***P<0.001. aDefined as an acute worsening of COPD symptoms requiring the use of additional treatment including oral corticosteroids, antibiotics, emergency department treatment, or hospitalization. bAny first exacerbation was also considered a sustained deterioration as patients were withdrawn by protocol following a first event.
Abbreviations: CI, confidence interval; CID, clinically important deterioration; FEV1, forced expiratory volume in 1 second; HR, hazard ratio; ITT, intent-to-treat; SGRQ, St George’s Respiratory Questionnaire; TIO, tiotropium; UMEC, umeclidinium; VI, vilanterol.

Time to sustained composite CID in Study A

The incidence of a sustained composite CID was approximately half that of a first CID with UMEC/VI (24%), UMEC (28%), VI (34%), and placebo (49%) (Table 2; Figure 1A). Compared with placebo, there was a statistically significant reduction of 61% in the risk of a sustained composite CID with UMEC/VI treatment (HR: 0.39 [95% CI: 0.30, 0.50]), 53% with UMEC (HR: 0.47 [95% CI: 0.37, 0.60]), and 40% with VI (HR: 0.60 [95% CI: 0.47, 0.76]; all P<0.001) (Table 2; Figure 2C). Statistically significant reductions in the risk versus placebo of a deterioration in trough FEV1 were observed with UMEC/VI, UMEC, and VI (P<0.001) (Table 2). UMEC/VI also produced a statistically significant reduction of 35% in the risk of a sustained composite CID versus VI (HR: 0.65 [95% CI: 0.50, 0.84]; P<0.001) but not with UMEC (Table 2).

Time to sustained composite CID in Study B

The incidence of sustained composite CIDs was 20% with UMEC/VI treatment and 33% with TIO (Table 3; Figure 1B). These values were approximately half that observed for a first composite deterioration (Table 3). UMEC/VI produced a statistically significant reduction of 47% in the risk of a sustained composite CID (HR: 0.53 [95% CI: 0.40, 0.68]; P<0.001) versus TIO (Table 3; Figure 2D). Statistically significant reductions in risk versus TIO were also observed for sustained deteriorations in trough FEV1 and SGRQ total score (P<0.05) (Table 3).

GOLD severity and concurrent ICS use subgroups in Studies A and B

In Study A, the incidence of a first CID was consistently highest in patients treated with placebo in all subgroups (69%–80%) compared with UMEC/VI (40%–48%), UMEC (47%–53%), and VI (54%–58%) (Table S3). All bronchodilator treatments statistically significantly reduced the risk of a first deterioration versus placebo in all subgroups (P<0.001). A statistically significant reduction in the risk of a first composite CID with UMEC/VI versus UMEC and VI in GOLD D and concurrent ICS use subgroups was observed (P<0.01; Table S3). Similar results were seen for sustained composite CID with the exception that UMEC/VI did not statistically significantly reduce the risk of a sustained composite CID in the concurrent ICS use subgroup versus UMEC (Table S3).

In Study B, the incidence of a first CID with TIO (55%–64%) and UMEC/VI (40%–43%) was similar in all subgroups (Table S4). UMEC/VI treatment statistically significantly reduced the risk of a first composite CID in all subgroups versus TIO (P<0.01) (Table S4). Similar results were seen for sustained composite CID (Table S4).

Safety

The incidences of on-treatment AEs and serious AEs were similar between all treatment groups in both studies. Safety data from both studies have been previously published.4,6

Sensitivity analysis of time to first and sustained CID in Study B

An analysis excluding FEV1 data from the four of seven visits where no SGRQ data were collected was performed. The incidence of a first composite CID and first deterioration in trough FEV1 was 37% (n=169) and 15% (n=67) with UMEC/VI and 52% (n=236) and 27% (n=122) with TIO, respectively. UMEC/VI statistically significantly decreased the risk of a composite CID by 39% (HR: 0.61 [95% CI: 0.50, 0.75]; P<0.001). For a sustained CID, the incidence of a composite CID and deterioration in trough FEV1 with UMEC/VI was 17% (n=75) and 6% (n=26) and with TIO was 27% (n=123) and 11% (n=50), respectively. The risk of a sustained composite CID was statistically significantly decreased by 45% (HR: 0.55 [95% CI: 0.41, 0.73]; P<0.001). These trends were similar to the primary analysis.

Discussion

In COPD management, treatment goals aim to reduce symptoms, improve health status, increase exercise tolerance, prevent exacerbations, and decrease disease progression.1 As lung function, health status, and exacerbations all contribute to long-term prognosis, COPD guidelines recommend that these parameters be considered when assessing disease progression and severity.1,1218 The results of this exploratory analysis, using a new assessment of clinical deterioration in COPD, showed that 75% of placebo-treated patients in Study A and 59% of TIO-treated patients in Study B reported a composite CID during the 24-week study period. The risk of a first CID was reduced with UMEC/VI treatment compared with TIO, UMEC, VI, or placebo.

Considering the individual components of the composite CID measure, deteriorations in lung function were the most commonly reported individual CID, followed by declines in health status and then moderate-to-severe COPD exacerbations. This may be largely explained by the higher frequency of lung function measurements compared with health status in the original 24-week studies and the recruitment of study populations without a history of frequent exacerbations. In Study A, both dual bronchodilation with UMEC/VI and mono-bronchodilation with UMEC reduced the risk of a first composite CID, as well as the risk of a first clinical deterioration of the individual CID parameters (lung function, health status, and moderate-to-severe exacerbations) compared with placebo. Decreases in risk of a first CID were also observed with VI monotherapy, although this did not include a reduction in the risk of moderate-to-severe exacerbations. Overall, the dual bronchodilator UMEC/VI provided greater protection from a first CID and decreased the risk of deteriorations in trough FEV1 compared with UMEC or VI bronchodilator monotherapy, potentially due to improved airway stability.

In Study B, patients treated with UMEC/VI experienced a statistically significant benefit in preventing first composite CID and a first deterioration in all three individual parameters compared with TIO. This suggests that dual bronchodilation provides greater stability than the recommended first-line mono-bronchodilator treatment in symptomatic patients with COPD.1,6 These findings also suggest that dual bronchodilation with UMEC/VI, in addition to producing statistically significant improvements in lung function and PROs compared with TIO,6,8 also provides greater protection against future deteriorations.

Deteriorations in lung function and health status could be transient or sustained. In Studies A and B, approximately half of all patients who experienced a first deterioration in lung function and a third of patients with a first deterioration in health status also developed a sustained deterioration. In Study A, as with first CID, UMEC/VI and its bronchodilator mono-components reduced the risk of a sustained composite CID compared with placebo. Overall, as with first CID, the greatest reduction in the risk of a sustained CID was with UMEC/VI dual bronchodilation. UMEC/VI provided a statistically significant reduction in the risk of sustained composite CIDs compared with VI and placebo but not with UMEC. In contrast, Study B showed that UMEC/VI compared with the LAMA TIO provided increased protection from a sustained composite CID and individual sustained deteriorations in trough FEV1 and health status. Overall, these results suggest increased protection from sustained CID by UMEC/VI compared with bronchodilator monotherapy.

Currently, it is unclear whether sustained CIDs have greater clinical consequences or prognostic implications than first CIDs on patients with COPD, and the long-term impact of a CID on other aspects of COPD morbidity and mortality requires further investigation. Many COPD exacerbations are not reported to health care professionals, remain untreated, and are associated with worse SGRQ scores.17 In the current study, it is possible that deteriorations in FEV1 and SGRQ total score could be unreported exacerbations and may also have a detrimental long-term impact. Furthermore, the threshold at which deteriorations are considered clinically significant requires further investigation. The thresholds used in the current study were based on recognized MCIDs for changes in lung function and health status.11,1820 Alternative cutoff points for deterioration could be explored in future studies to improve understanding of the relationship between CID thresholds and long-term outcomes, and whether this varies with the severity of the population. While we postulate that a CID represents a period of disease worsening, prospective long-term studies are required to expand on these initial post hoc findings and increase understanding of the prognostic weighting of each individual component of CID to the risk of future long-term COPD deteriorations.

COPD deteriorations appeared to be largely independent of baseline airflow limitation, although results for concomitant ICS were inconsistent. Patients with symptomatic COPD with both moderate lung function impairment and low exacerbation risk (GOLD B) or severe-to-very-severe lung function impairment and high exacerbation risk (GOLD D) both reported similar rates of a first CID with placebo in Study A and with TIO in Study B. In Study A, higher rates of a first CID with placebo were seen in patients using concomitant ICS (80%) compared with those not using ICS (69%). In Study B, patients treated with TIO monotherapy with concurrent ICS use experienced a lower incidence of a first CID (55%) compared with those not using ICS (64%). These contrasting findings mean that we can neither confirm nor exclude the possibility that ICS may contribute to the stabilization of COPD, and further investigation is required to address this question.

Independent of the influence of GOLD group or concurrent ICS use, dual and mono-bronchodilators reduced the risk of first and sustained composite CID compared with placebo in Study A. Additionally, in Study A, UMEC/VI treatment resulted in further risk reductions in first composite CID compared with UMEC and VI and sustained composite CID compared with VI in the GOLD D and concurrent ICS use subgroups. In Study B, UMEC/VI produced a statistically significant reduction in first and sustained composite CID in all subgroups compared with TIO suggesting that the benefits of UMEC/VI compared with TIO are consistent across a range of patient subgroups with differing COPD symptom burden. Reductions in the risk of a CID with UMEC/VI versus monotherapy were more consistent across subgroups in Study B than Study A. This raises the possibility that there may be differences between bronchodilator monotherapies in the ability to prevent a CID.

One study limitation was that results were derived from a post hoc analysis of trials not designed to evaluate CIDs. Also, data were obtained from two short-term 24-week studies, which enrolled only patients with moderate-to-very-severe lung function impairment and moderate-to-very-severe COPD symptoms but a low risk of COPD exacerbations. A longer period may be required to determine the effect of dual- and mono-bronchodilator treatments on exacerbations as a component of the CID end point in patients with a low exacerbation risk, while 24 weeks may be sufficient to assess patients with a higher exacerbation risk. Unsurprisingly, deteriorations in lung function and SGRQ total score were more common than exacerbations in this population of patients with a low exacerbation risk. As lung function was assessed at seven clinic visits and SGRQ total score at only three, a sensitivity analysis was performed to exclude lung function data when there was no concurrent SGRQ total score assessment. This analysis was consistent with the primary analysis, suggesting that results for the composite CID end point were not driven by the overrepresentation of the lung function component. Nevertheless, retrospective and prospective studies are required to further validate the CID end point in different populations of patients receiving different treatment combinations. Additionally, it may be beneficial to investigate the impact of including other PROs that respond to pharmacotherapy, such as the transition dyspnea index.22 Finally, it remains to be determined whether these deteriorations are linked with reduced activity levels, associated with poor COPD prognosis.2326

Overall, these results suggest that long-acting dual-bronchodilator therapy may provide greater airway stability, and protection from deteriorations in lung function and health status and the occurrence of exacerbations compared with TIO or VI monotherapies. Interestingly, the combination of the short-acting bronchodilators ipratropium and albuterol, which has the same mechanism of action as LAMA/LABA combinations, also reduces daily variation in lung function compared with monotherapy.27 A reduction in the daily variation of lung function may lead to more consistent long-term reductions in COPD symptoms.17

Current COPD management guidelines recommend that lung function, health status, and exacerbations should all be considered when assessing disease progression and severity,1 as all have been shown to contribute to long-term prognosis.1218 By using a threshold at which these deteriorations are considered clinically important, the composite first and sustained CID end points may provide new insights on the effects of bronchodilators in COPD management.11,19 It is established that UMEC/VI improves lung function, health status, and symptoms compared with placebo or mono-bronchodilator therapy.4,6 The current study highlights a new and important aspect of the benefit of dual therapy with UMEC/VI.

Conclusion

These results show that patients with COPD experience frequent CIDs involving lung function, health status, and the occurrence of moderate-to-severe exacerbations. Dual-bronchodilator therapy with UMEC/VI may reduce the risk of these CIDs compared with long-acting bronchodilator monotherapy or placebo.

Acknowledgments

The authors wish to thank Alex Lowe, PhD, from Fishawack Indicia Ltd, who provided editorial assistance with developing this manuscript (in the form of writing assistance, including development of the initial draft, assembling tables and figures, collating authors’ comments, grammatical editing, and referencing), funded by GSK. This study was funded by GSK (GSK analysis #202065), and used data from two clinical trials which were also funded by GSK (DB2113373/NCT01313650 and ZEP117115/NCT01777334).

Author contributions

All authors contributed toward data analysis, drafting and revising the paper and agree to be accountable for all aspects of the work.

Disclosure

DS has received sponsorship to attend international meetings, honoraria for lecturing or attending advisory boards, and research grants from various pharmaceutical companies including Almirall, AstraZeneca, Boehringer Ingelheim, Chiesi, Genentech, GSK, Glenmark, Johnson & Johnson, Merck, NAPP, Novartis, Pfizer, Skyepharma, Takeda, Teva, Theravance, and Verona. MRM-Y acted as a consultant for Almirall, AstraZeneca, Boehringer Ingelheim, Forest Laboratories, GSK, Novartis, Merck, Ono Pharmaceuticals, and Pfizer. LT is a contingent worker at GSK. AI was an employee of GSK at the time of analysis completion and holds stock/shares in GSK. WF and IN are employees of GSK and hold stocks/shares in GSK. The authors report no other conflicts of interest in this work.


References

1.

GOLD. Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease. 2015. Available from: http://www.goldcopd.com/. Accessed August 12, 2015.

2.

Dransfield MT, Bailey W, Crater G, Emmett A, O’Dell DM, Yawn B. Disease severity and symptoms among patients receiving monotherapy for COPD. Prim Care Respir J. 2011;20(1):46–53.

3.

Singh D. New combination bronchodilators for chronic obstructive pulmonary disease: current evidence and future perspectives. Br J Clin Pharmacol. 2015;79(5):695–708.

4.

Donohue JF, Maleki-Yazdi MR, Kilbride S, Mehta R, Kalberg C, Church A. Efficacy and safety of once-daily umeclidinium/vilanterol 62.5/25 mcg in COPD. Respir Med. 2013;107(10):1538–1546.

5.

Celli B, Crater G, Kilbride S, et al. Once-daily umeclidinium/vilanterol 125/25 mcg in COPD: a randomized, controlled study. Chest. 2014;145(5):981–991.

6.

Maleki-Yazdi MR, Kaelin T, Richard N, Zvarich M, Church A. Efficacy and safety of umeclidinium/vilanterol 62.5/25 mcg and tiotropium 18 mcg in chronic obstructive pulmonary disease: results of a 24-week, randomized, controlled trial. Respir Med. 2014;108(12):1752–1760.

7.

Oba Y, Sarva ST, Dias S. Efficacy and safety of long-acting beta-agonist/long-acting muscarinic antagonist combinations in COPD: a network meta-analysis. Thorax. 2016;71(1):15–25.

8.

Decramer M, Anzueto A, Kerwin E, et al. Efficacy and safety of umeclidinium plus vilanterol versus tiotropium, vilanterol, or umeclidinium monotherapies over 24 weeks in patients with chronic obstructive pulmonary disease: results from two multicentre, blinded, randomised controlled trials. Lancet Respir Med. 2014;2(6):472–486.

9.

Bateman ED, Ferguson GT, Barnes N, et al. Dual bronchodilation with QVA149 versus single bronchodilator therapy: the SHINE study. Eur Respir J. 2013;42(6):1484–1494.

10.

Siler TM, Kerwin E, Sousa AR, Donald A, Ali R, Church A. Efficacy and safety of umeclidinium added to fluticasone furoate/vilanterol in chronic obstructive pulmonary disease: results of two randomized studies. Respir Med. 2015;109(9):1155–1163.

11.

Jones PW. St George’s Respiratory Questionnaire: MCID. COPD. 2005;2(1):75–79.

12.

Donaldson GC, Seemungal TA, Bhowmik A, Wedzicha JA. Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease. Thorax. 2002;57(10):847–852.

13.

Schmidt SA, Johansen MB, Olsen M, et al. The impact of exacerbation frequency on mortality following acute exacerbations of COPD: a registry-based cohort study. BMJ Open. 2014;4(12): e006720.

14.

Sin DD, Man SF. Chronic obstructive pulmonary disease as a risk factor for cardiovascular morbidity and mortality. Proc Am Thorac Soc. 2005;2(1):8–11.

15.

Sin DD, Wu L, Man SF. The relationship between reduced lung function and cardiovascular mortality: a population-based study and a systematic review of the literature. Chest. 2005;127(6):1952–1959.

16.

Tockman MS, Pearson JD, Fleg JL, et al. Rapid decline in FEV1. A new risk factor for coronary heart disease mortality. Am J Respir Crit Care Med. 1995;151(2 Pt 1):390–398.

17.

Jones PW, Lamarca R, Chuecos F, et al. Characterisation and impact of reported and unreported exacerbations: results from ATTAIN. Eur Respir J. 2014;44(5):1156–1165.

18.

Wilke S, Jones PW, Mullerova H, et al. One-year change in health status and subsequent outcomes in COPD. Thorax. 2015;70(5):420–425.

19.

Donohue JF. Minimal clinically important differences in COPD lung function. COPD. 2005;2(1):111–124.

20.

Westwood M, Bourbeau J, Jones PW, Cerulli A, Capkun-Niggli G, Worthy G. Relationship between FEV1 change and patient-reported outcomes in randomised trials of inhaled bronchodilators for stable COPD: a systematic review. Respir Res. 2011;12:40.

21.

Celli BR, MacNee W. Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. Eur Respir J. 2004;23(6):932–946.

22.

Witek TJ Jr, Mahler DA. Minimal important difference of the transition dyspnoea index in a multinational clinical trial. Eur Respir J. 2003;21(2):267–272.

23.

Garcia-Rio F, Rojo B, Casitas R, et al. Prognostic value of the objective measurement of daily physical activity in patients with COPD. Chest. 2012;142(2):338–346.

24.

Vaes AW, Garcia-Aymerich J, Marott JL, et al. Changes in physical activity and all-cause mortality in COPD. Eur Respir J. 2014;44(5):1199–1209.

25.

Waschki B, Spruit MA, Watz H, et al. Physical activity monitoring in COPD: compliance and associations with clinical characteristics in a multicenter study. Respir Med. 2012;106(4):522–530.

26.

Watz H, Waschki B, Meyer T, Magnussen H. Physical activity in patients with COPD. Eur Respir J. 2009;33(2):262–272.

27.

Singh D, Zhu CQ, Sharma S, Church A, Kalberg CJ. Daily variation in lung function in COPD patients with combined albuterol and ipratropium: results from a 4-week, randomized, crossover study. Pulm Pharmacol Ther. 2015;31:85–91.

Supplementary materials

Table S1 Summary of trough FEV1 at day 169 and SGRQ total score at day 168 in Study A (ITT population)
Abbreviations: FEV1, forced expiratory volume in 1 second; ITT, intent-to-treat; LS, least squares; SE, standard error; SGRQ, St George’s Respiratory Questionnaire; TIO, tiotropium; VI, vilanterol; UMEC, umeclidinium; L, liters.

Table S2 Summary of trough FEV1 at day 169 and SGRQ total score at day 168 in Study B (ITT population)
Abbreviations: FEV1, forced expiratory volume in 1 second; ITT, intent-to-treat; LS, least squares; SE, standard error; SGRQ, St George’s Respiratory Questionnaire; TIO, tiotropium; VI, vilanterol; UMEC, umeclidinium.

Table S3 Summary of first and sustained composite CID by subgroup in Study A (ITT population)
Notes: *P<0.05; **P<0.01; ***P<0.001. aAny first exacerbation was also considered a sustained deterioration as patients were withdrawn by protocol following a first event.
Abbreviations: CI, confidence interval; CID, clinically-important deterioration; GOLD, Global initiative for chronic Obstructive Lung Disease classification; HR, hazard ratio; ICS, inhaled corticosteroid; ITT, intent-to-treat; VI, vilanterol; UMEC, umeclidinium.

Table S4 Summary of first and sustained composite CID by subgroup in Study B (ITT population)
Notes: **P<0.01; ***P<0.001. aAny first exacerbation was also considered a sustained deterioration as patients were withdrawn by protocol following a first event.
Abbreviations: CI, confidence interval; CID, clinically important deterioration; GOLD, Global initiative for chronic Obstructive Lung Disease classification; HR, hazard ratio; ICS, inhaled corticosteroid; ITT, intent-to-treat; TIO, tiotropium; VI, vilanterol; UMEC, umeclidinium.

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