Prevalence of Refractive Error and Visual Acuity Among School Children in the Plateau Region of Qinghai, China

Introduction

Refractive errors such as hyperopia, myopia and astigmatism are the most general ocular disorders requiring spectacles or contact lenses for optimal vision. Refractive error is caused by the mismatch between the various optical elements of the eye, and the eye’s axial length is one reason.¹ Uncorrected errors of refraction are the most common causes of visual disability worldwide.² The prevalence of refractive error varies with sex, geographic location and age.^3–6

Myopia is a widespread refractive error among children and teenagers and is globally recognized as a major twenty-first century public health problem.^7,8 Dong et al speculated that the myopia prevalence in 2050 among Chinese children and adolescents aged 3 to 19 years will be approximately 84%.⁹ Myopia causes further vision challenges because high myopia increases the risk of severe and irreversible vision loss, such as cataracts, glaucoma, retinal detachment, and myopic macular degeneration.¹⁰ Thus, preventing the occurrence and development of myopia in children and adolescents is crucial.

Myopia is associated with genetic, behavioral, social and environmental factors, including socioeconomic status, educational attainment,¹¹ time spent outdoors,¹² outdoor light intensity¹³ and time spent reading.¹⁴ Although previous studies have provided valuable insights into the etiology of myopia, natural environmental factors have largely been neglected. Many reports have investigated the prevalence of myopia in China’s plains,^15–18 but few reports are available on the prevalence of myopia in the northwest plateau.

The Qinghai-Tibet Plateau is the largest plateau worldwide. This area is characterized by low temperature, large temperature differences between day and night, long sunshine, strong solar radiation, high altitude, and thin oxygen. The high altitude and special climate on the Qinghai-Tibet Plateau can affect people’s physical and mental health, such as hypertension,¹⁹ cardiovascular diseases,²⁰ cognitive impairments²¹ and depression.²² These specific geographical environments also affect eye health,²³ including pterygium, cataracts, and dry eye syndrome. Few reports have examined the prevalence of myopia among children on the Qinghai-Tibet Plateau. Only 3 previous reports on Qinghai-Tibet Plateau school children are available to date. The first study reported that from 2008 to 2009, the prevalence of myopia was 11.8% in primary school students in Qinghai.²⁴ The second study reported that in 2014, among children and adolescents aged 7 to 18 years, the prevalence of myopia was 48.2% in Qinghai and 62.9% in Tibet.²⁵ The third study reported that in 2018, the prevalence of myopia in Tibet was 23.83% among children, with a mean age of 12.69 (±2.88) years.²⁶

No epidemiological study has been performed on refractive error in school children in Qinghai in the past 5 years. We selected Menyuan Hui Autonomous County (Menyuan) in Qinghai Province as the study site. Through ocular examination, we analyzed the refractive status and vision acuity in Qinghai Province.

Materials and Methods

Ethics Statement

This study was approved by the ethics committee of the Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine and Administration of the Education and School Board of Menyuan. This study adhered to the tenets of the Declaration of Helsinki. Additionally, we obtained written informed consent from at least one parent or legal guardian of each participant.

Recruitment

The pediatric eye study was a school-based, cross-sectional study of children in the northwest Chinese province of Qinghai conducted in Menyuan in September 2019. The sampling frame was based on 11 kindergartens and 12 primary schools with approximately 18,381 children throughout Menyuan, excluding special schools for the disabled. Three kindergartens and 3 primary schools from both rural areas and county towns were selected randomly.

Ophthalmic Examination

The children had undergone the following examinations: distance visual acuity (VA) testing, intraocular pressure (IOP), cover test, slit-lamp examination, fund examination, cycloplegic autorefraction, and axial length (AL).

Before the VA test, the children were asked whether they wore glasses, contact lenses or orthokeratology contact lenses. For the children not wearing glasses, the uncorrected visual acuity (UCVA) and best corrected visual acuity (BCVA) were tested for both eyes. For those wearing glasses, presenting visual acuity (PVA) was first measured, and then UCVA was measured after removing the glasses for 30 minutes. BCVA was examined by subjective refraction by experienced optometrists. VA was measured using a tumbling “E” chart (#600722; Good-Lite Co., Elgin, IL, USA) (the VA chart was 3 meters away from the child. The lowest line of the chart was approximately as high as the eye of the child. The children were asked to indicate the direction of the “E” opening starting on the first line of the chart (VA: 20/100) and moving on to the next line if none or one character of the line was incorrect. When the child incorrectly described at least 2 characters, VA was recorded as the value of the previous line. If the children could not read 20/100 lines at a distance of 3 meters, the test was repeated at one meter. If a single line could not be read at this distance, vision was assessed by counting fingers, hand movement or light perception.

The purpose of IOP measurement and slit-lamp examination was to exclude contraindications for mydriasis. Cycloplegia was achieved after instilling one drop of topical anesthetic ((Minims Oxybuprocaine Hydrochloride 0.4% w/v; Santen Pharmaceutical Co., Ltd; Japan) and one drop of cyclopentolate hydrochloride (Minims; 1% w/v; Alcon Laboratories, Inc; USA). The children were administered two drops of cyclopentolate hydrochloride 5 min apart. Once cycloplegia had been established, at least 20 min after instilling the eye drops, autorefraction was performed. Full cycloplegia was considered when the pupil diameter reached 6 mm or more and the light reflex disappeared. The presence of refraction with cycloplegia was assessed using an autorefractor (ARK-1; NIDEK, Tokyo, Japan). AL was measured using an IOL Master-500 (Carl Zeiss Meditec AG, Jena, Germany).

All the above instruments were calibrated before the ocular examination. All the examinations were performed by board-certified ophthalmologists and certified optometrists.

Definitions

Refraction measurements were converted into spherical equivalent refraction (SER), which was calculated as the spherical value plus half of the astigmatism value. Medium to marked hyperopia was defined as >+2.0 dioptres (D), and mild hyperopia was defined as >+0.50 D and ≤+2.0 D, in one or both eyes if neither eye was myopic. Emmetropia was defined as >−0.50 D and ≤+0.50 D, in both eyes. Myopia was defined as≤−0.5 D and high myopia as≤−6.0 D, in one or both eyes. Astigmatism was defined as a myopic cylindrical refractive error≤−0.75 D in either eye. All refractive errors were measured under cycloplegia.

For the students not wearing glasses, PVA is equivalent to UCVA; for those wearing glasses, PVA is equivalent to VA of wearing spectacles.

Statistical Methodology

Statistical analyses were performed using SPSS 19.0 (SPSS Inc., Chicago, IL). For normally distributed continuous variables, the data were expressed as means ± standard deviation (SD). Categorical variables were expressed as frequencies of the total. The risk factors associated with myopia were determined by two-level multivariate logistic regression analysis. First, we performed univariate binary logistic regression analysis to evaluate the potential association. Multivariate logistic regression was then performed to analyze all statistically significant factors found in the univariate analysis. For continuous variables, we conducted univariate analysis to identify correlations and then performed linear regression analysis. In our results, odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate myopia risk factors. OR<1.0 and P<0.05 demonstrated that a parameter was a protective factor, while OR>1.0 and P<0.05 demonstrated that a parameter was a risky factor. Statistical tests were two-sided, and P<0.05 was considered statistically significant.

Results

Participant Characteristics

During September 2019, 3770 participants were recruited. Of these, 233 (6.18%) children refuse to participate and not signed informed consent, 13 (0.34%) with an IOP≥25 mmHg in one or both eyes were excluded from the study, and 3524 completed the ophthalmic examinations, resulting in a complete examination rate of 93.47%. The demographic characteristics of the study population are described in Table 1.

Table 1 The Demographic Characteristics of the Study Participants

The mean age of the 3524 participants was 8.3±2.3 years (4–12 years). Of the 3524 participants, 1798 (51.0%) resided in rural areas, and 1726 (49.0%) resided in county towns. The participants comprised more boys (1825; 51.8%) than girls (1699; 48.2%) among, but no significant difference was found in the sex between participants in rural areas (53.4% boys) and county towns (50.1% boys) (χ²= 3.787; P=0.052).

Ocular Parameters

A significant difference was found in SER between the right and left eyes (t=2.071; P=0.038). The mean SER of the right eyes was −0.16±1.86 D (median: 0.38 D; range: −16.5 D to +11.75 D) and that of the left eyes was −0.05±1.80 D (median: 0.38 D; range: −13.25 D to +12.00 D). Pearson correlation analysis of the SER showed a high correlation (r=0.914; P=0.000) between the right and left eyes. Therefore, only the SER of the right eyes was analyzed in our study.

The mean SER of children in the county towns (−0.44±2.08 D) showed a greater refractive change toward myopia than that of children in rural areas (0.02±1.68 D) (t=−5.983; P=0.000). The SER decreased within children aged 4 to 12 years in county towns (F=47.385; P=0.000) and rural areas (F=44.944; P=0.000) (Figure 1A). In the county towns, the SERs were 1.25±0.59, 1.19±0.55, 1.26±1.51, 0.41±0.97, 0.16±1.77, −0.62±1.91, −1.19±2.09, −1.72±2.34 and −1.80±1.96 D in children aged 4 to 12 years. In the rural areas, the SERs were 1.18±0.55, 1.17±0.55, 1.09±0.90, 0.81±0.72, 0.42±1.83, 0±1.55, −0.58±1.60, −0.79±1.87 and −0.95±1.72 D in children aged 4 to 12 years.

Figure 1 Spherical equivalent (SE, D) distribution of right eyes, (A) stratified by age and region of habitation, (B) stratified by age and genders in the Qinghai children. The Y axis shows the mean and 95% confidence interval.

The SER was −0.09±1.79 D in boys and −0.24±1.94 D in girls, and the difference was statistically significant (t=2.040; P=0.041). The SER decreased with age in both boys and girls but was more pronounced in girls (Figure 1B). In boys, the SERs were 1.22±0.68, 1.11±0.59, 0.93±0.64, 0.67±0.85, 0.28±1.83, −0.2±1.69, −0.77±1.8, −0.99±2.11 and −1±1.78 D in those aged 4 to 12 years. In girls, the SERs were 1.201±0.46, 1.29±0.45, 1.44±1.49, 0.6±0.86, 0.39±1.81, −0.22±1.73, −0.86±1.86, −1.39±2.12 and −1.59±1.9 D in those aged 4 to 12 years.

The AL was significantly longer with each older age, from 21.80±0.59 mm in 4-year-olds to 23.53±1.05 mm in 12-year-olds (F=98.006; P=0.000). The AL of children in county towns (23.25±1.20 mm) was longer than that in rural areas (22.81±1.03 mm) (t=−7.156; P=0.000) (Figure 2A). In the county towns, the ALs were 21.8±0.6, 21.93±0.72, 22.37±0.93, 22.72±0.72, 22.84±1.02, 23.36±0.96, 23.62±1.10, 23.92±1.13 and 23.83±1.21 mm in children aged 4 to 12 years. In the rural areas, the ALs were 21.81±0.59, 22.01±0.7, 22.26±0.69, 22.33±0.84, 22.63±1.04, 22.84±0.96, 23.19±0.98, 23.32±1.02 and 23.34±0.89 mm in children aged 4 to 12 years.

Figure 2 Axial length (AL, mm) distribution of right eyes, (A) stratified by age and region of habitation, (B) stratified by age and genders in the Qinghai children. The Y axis shows the mean and 95% confidence interval.

The difference in the AL between boys (23.16±1.07 mm) and girls (22.70±1.11 mm) was statistically significant (t=10.930; P=0.000) (Figure 2B). In boys, the ALs were 22.09±0.61, 22.25±0.57, 22.58±0.64, 22.77±0.77, 22.93±0.95, 23.28±0.96, 23.66±1.00, 23.74±1.09 and 23.61±1.10 mm in those aged 4 to 12 years. In girls, the ALs were 21.59±0.48, 21.58±0.71, 21.88±0.73, 22.19±0.74, 22.46±1.08, 22.76±0.96, 23.07±1.01, 23.34±1.08 and 23.44±0.99 mm in those aged 4 to 12 years.

Prevalence of Refractive Errors

The prevalence of myopia was 29.8% (95% CI: 20.7%, 39.0%) in the 3524 children (Table 2). The prevalence of myopia increased with age from 2.0% (95% CI: −1.7%, 6.2%) in 4-year-olds to 62.8% (95% CI: 42.6%, 83.6%) in 12-year-olds (Table 3 and Figure 3). Univariate binary logistic regression analysis demonstrated that the prevalence of myopia was significantly associated with girls (P=0.043), increasing age (P=0.000) and habitation in county towns (P=0.000). The results of multivariate binary regression analysis revealed that the prevalence of myopia was higher in female students than in male students, and female students had a 1.22-fold higher risk of myopia than male students [OR: 1.22 (95% CI: 1.03, 1.45); P=0.043]. The results also indicated that the prevalence of myopia increased with age [OR: 1.84 (95% CI: 1.75, 1.93); P=0.000]. Furthermore, children living in county towns [OR: 1.53 (95% CI: 1.29, 1.80); P=0.000] had a higher risk of myopia than those living in rural areas.

Table 2 Distribution of Prevalence of Various Refractive Error in Different Genders and Regions

Table 3 Distribution of Prevalence of Various Refractive Errors at Different Ages Between 4–12 Years Old

Figure 3 Prevalence of high myopia, myopia, emmetropia, mild hyperopia and medium to marked hyperopia, stratified by age in the Qinghai children. Participants were classified according to SER into high myopia (SER≤−6.0D), myopia (SER≤−0.5 D), emmetropia (SER>−0.50 D and ≤+0.5 D), mild hyperopia (SER>+0.50 D and ≤+2.0 D), and medium to marked hyperopia (>+2.0 D).

The prevalence of high myopia was 0.9% (Table 2) in total and increased from 0% in the 4-year-old group to 2.1% in the 12-year-old group (Table 3). In univariate binary logistic regression analysis, the prevalence of high myopia was significantly associated with increasing age (P=0.000), but it was not significantly associated with region of habitation (P=0.229) or sex (P=0.191). As the children became older, their risk of high myopia increased [OR: 1.67 (95% CI: 1.33, 2.09); P=0.000].

The prevalence of mild hyperopia was 48.0% in total (Table 2) and decreased from 89.1% in the 4-year-old group to 16.7% in the 12-year-old group (Table 3). Univariate binary logistic regression analysis showed that the prevalence of mild hyperopia was significantly associated with increasing age (P=0.000), but it was not significantly associated with region of habitation (P=0.512) or sex (P=0.970). As the children became older, their risk of mild hyperopia decreased (OR: 0.60 [95% CI: 0.57, 0.62]; P=0.000).

The prevalence of medium to marked hyperopia was 4.3% in total (Table 2) and decreased from 5% in the 4-year-old group to 1.0% in the 12-year-old group (Table 3). Univariate analysis showed that the prevalence of medium to marked hyperopia was significantly associated with increasing age (P=0.001), but was not associated with region of habitation (P=0.672) or sex (P=0.405). As children became older, their risk of medium to marked hyperopia decreased (OR: 0.89 [95% CI: 0.83, 0.95]; P=0.001).

The prevalence of astigmatism was 26.2% in total (Table 2), and the mean value of astigmatism was 0.43±0.51 D (median: −0.25 D; range: −7.00 D to 0 D). Univariate analysis showed that the prevalence of astigmatism was significantly associated with age [regression coefficient B=−0.02; standardized coefficients beta=−0.10; P=0.000; (95% CI: −0.03, −0.02)], region of habitation (P=0.009), sex (P=0.033) and myopic refractive error [regression coefficient B=0.02; standardized coefficients beta=0.07; P=0.000; (95% CI: 0.01, 0.03)]. In binary regression analysis, older age [OR: 1.09 (95% CI: 1.04, 1.13); P=0.000], habitation in county towns [OR: 1.19 (95% CI: 1.02, 1.39); P=0.000], and more myopic refractive error [B=−1.06; OR: 0.90 (95% CI: 0.86, 0.94); P=0.000] were associated with a higher astigmatism prevalence. Girls [OR: 0.85 (95% CI: 0.73, 0.99); P=0.035] were associated with a lower prevalence of astigmatism.

Visual Acuity and Glasses Wear

In high myopia, myopia and medium to marked hyperopia, the uncorrected visual acuity (UCVA) and presenting visual acuity (PVA) were significantly lower than those in emmetropia, while no difference was found in UCVA (P=0.105) and PVA (P=0.193) between mild hyperopia and emmetropia. The best corrected visual acuity (BCVA) in high myopia (P=0.000) and medium to marked hyperopia (P=0.000) was significantly lower than that in emmetropia, but no difference was found in the BCVA in mild hyperopia (P=0.866), myopia (P=0.283) and emmetropia. High myopia and medium to marked hyperopia affected the children’s vision.

The VA results are presented in Table 4. Refractive errors were the main reason for UCVA 20/40 or worse. Of the 3524 participants, 2917 (82.8%) had a UCVA of 20/30 or better in at least one eye, 607 (17.2%) had a UCVA of 20/40 or worse in the better eye, and 411 (11.7%) had a PVA of 20/40 or worse in the better eye. With best correction, VA 20/40 or worse in the better eye decreased to 40 (1.1%). Among the 891 participants with UCVA 20/40 or worse in one eye, 812 (91.1%) were caused by uncorrected refractive error. Among the 723 participants with PVA 20/40 or worse in one eye, 564 (78.0%) were caused by uncorrected refractive error, and 83 (22.0%) were caused by undercorrected refractive error.

Table 4 The Uncorrected, Present and Best Corrected Visual Acuity (UCVA, PVA and BCVA) Distribution

All the participants were asked to bring their spectacles to the school on the day of the ocular examination. In the 3524 participants with reliable VA, glasses were only used by 288 (8.2%). Two hundred fifty-four participants wore glasses due to myopia, which was the main reason for them to wear glasses. Additionally, among the 1049 myopic participants, 795 (75.8%) participants presented without glasses. Furthermore, 302 (38.0%) participants without glasses had a UCVA of 20/40 or worse in the better eye (Table 5). Among 254 (24.2%) myopic participants who wore glasses, 44 (17.3%) had a PVA 20/40 or worse in the better eye, and 151 (59.4%) presenting with PVA had a worse BCVA and did not have accurate spectacles.

Table 5 The Distribution of Presenting Visual Acuity (PVA) and Best Corrected Visual Acuity (BCVA) Among Myopic Participants

Discussion

Menyuan is located on the high-altitude Qinghai-Tibet Plateau, and the environment is expected to affect the eye health of children living there, but little is known about the prevalence of refractive error in the northwest plateau region. Therefore, we investigated the characteristics of refractive error among school-aged children.

In our study, the boys living in the county town and with older age had longer eyes. Higher AL was related to older age of the children.²⁷ In the current study, the AL became significantly longer with each older age from 21.80±0.59 mm in 4-year-olds to 23.53±1.05 mm in 12-year-olds. Male sex was a significant and independent factor for a longer axial length.²⁸ In the present data, the AL was longer in boys than in girls, a finding that agrees with a previous study.^28,29 The mean AL in our study was 23.61±1.10 mm for boys and 23.44±0.99 mm for girls at 12 years old. The values were slightly shorter than the ALs obtained in one Eastern Chinese study on children of the same age (boys: 24.14±1.01 mm; girls: 23.69±1.10 mm). We found the same phenomenon as in previous studies²⁹ and at the same age: boys have longer ALs and higher refractive power than girls; however, the reasons must be further clarified.

The prevalence of myopia among 4- to 12-year-old children in Qinghai was 29.8%. Qian et al²⁶ reported that the prevalence of myopia was 23.83% in Tibet (12.69±2.88 years old). Xie et al³⁰ defined VA<20/20 and SER<−0.5D as myopia and found that the myopia prevalence of children aged 7–13 years in Chongqing was 33.1%. Wang et al¹⁶ defined myopia as SER≤−0.5 D and UCVA≤20/25 and reported that the myopia prevalence was 41.4% in Yiwu among 5- to 12-year-old children. Both Qinghai and Tibet are economically backward plateau regions, and they have similar myopia prevalences. The prevalence of myopia in Qinghai is not significantly lower than that in Chongqing and Yiwu economically developed areas. Our study, together with previous studies in school children, suggests that myopia is a serious public health problem in China, including plateau regions. The government should be aware of these findings and adopt measures to prevent myopia among children in China’s plateau regions.

Qinghai is characterized by low temperature, large temperature differences between day and night, long sunshine, and strong solar radiation, making children spend relatively less time in outdoor activities and increasing the possibility of myopia. Studies have shown that scleral hypoxia is one cause of myopia.³¹ The high altitude of Menyuan and low oxygen content in the air affect the oxygen supply of the eyes, a factor that may also affect myopia in children.

Myopia was significantly associated with increasing age, county town region of habitation and girls, findings that are consistent with previous study findings.^3–5 The learning burden increases with age, leading to more hours on near work activities and reduced time on outdoor activities, a situation considered to be an important risk factor for the occurrence of myopia.^32,33 The environment is an important factor in the prevalence of myopia, and county town children have a higher risk of myopia than rural area children subjected to the county town environment and learning pressure.^3,17 Regarding sex differences, girls tend to spend more time reading and writing and perform less outdoor activities, making them more vulnerable to developing myopia.³⁴

As children become older, their risk of high myopia increases. The prevalence of high myopia increased from 0.8% in 8-year-old patients to 2.1% in 12-year-old patients. In 12-year-olds, the prevalence of high myopia was lower than that in Beijing,³⁵ Qingdao,³⁶ Yiwu and Hong Kong,^16,37 and similar to that in Mongolia.³⁸ In our study, the prevalence of high myopia began to increase between the ages of 11 and 12 years in Qinghai, beginning later than in the developed plains areas of Beijing,³⁵ Qingdao,²⁶ Yiwu,¹⁶ and Hong Kong,³⁷ but close to the same age in the underdeveloped plains areas of Yunnan³⁹ and Mongolia.³⁸ Early myopia onset generally leads to rapid and longer duration for myopia progression and, consequently, a higher risk of becoming high myopic later in life.

The prevalence of astigmatism varies according to geographical position and population. The astigmatism prevalence (26.2%, ≤−0.75 D, 4–12 years of age) was higher in Yunnan (12.7%, ≤−0.75 D, 13–14 years of age),⁴⁰ Beijing (10%, ≤−0.75 D, 5–15 years of age),⁴¹ and Wenzhou (20.3%, ≤−0.75 D, 6–9 years of age).⁴² Our prevalence was lower than that in other studies, where the prevalence was 42.7% in Guangzhou (≤−0.75 D, 5–15 years old) and 36.3% in Shandong (≤−0.75 D, 4–18 years of age).^4,43 Different studies have reported contradictory findings, and we detected correlations with age, region of habitation, sex and myopia refractive error, unlike those reported by Zhao et al, Lin et al and Fotouhi et al.^41,42,44

Uncorrected/undercorrected refractive error (particularly myopia) is the main reason for UCVA/PVA 20/40 or worse.^43,45,46 This type of vision problem can be easily solved by prescribing a pair of suitable spectacles. In the present study, only 24.2% of myopia students wore glasses, and 59.4% of them did not have accurate spectacles. Our finding was comparable to another study by Chin MP and colleagues, in which 64% of Chinese children in remote areas did not have appropriate correction.¹⁵ The wearing glass rate was lower than that in developed provinces of China (70.1% among those aged 5–18 years).¹⁶ In Menyuan, many children are “left-behind children” whose parents are too busy to care about their children’s eye health. The price of glasses is more expensive, and the inconvenience of wearing glasses may also be the reason for not wearing glasses among myopic children. Another potential reason for glasses nonwear among myopic children may be related to the widespread misunderstanding in China that young children wearing glasses might damage their visual acuity.⁴⁷ The lower appropriate rate of glasses use among Qinghai children may also be associated with poor access to health services.^48,49

The projected number of children and adolescents 7 to 18 years of age affected by reduced visual acuity is approximately 152 million in 2020 and approximately 180 million in 2030.⁵⁰ Visual impairment affects an individual’s quality of life and impedes access to education and employment.⁵¹ Therefore, in Qinghai, we should adopt certain measures and strategies, such as strengthening children’s vision screening, improving the local medical level, popularizing the knowledge of eye care, enhancing the awareness of children and parents of eye care, and providing optician subsidies, to reduce and delay the occurrence of myopia in children and adolescents.

Our study has potential limitations. Children aged 4–6 years are young, and many parents refuse to participate in the eye study because of concerns about pupil dilation. Therefore, relatively few children were included, which may have affected the calculation of the prevalence of refractive error. Additionally, astigmatism was related to sex, place of residence, age, and myopia, but some studies differ from ours, likely because of the different age groups and different criteria for astigmatism definition.

Conclusion

Refractive error in 4- to 12-year-old children, particularly children with myopia, is common in Northwest Plateau China. In our study, 29.8% of 4- to 12-year-old children had myopia, 0.9% had high myopia, 4.3% had medium to marked hyperopia, and 26.2% had astigmatism. Uncorrected/undercorrected refractive error (especially myopia) was the main reason for PVA 20/40 or worse. A total of 75.8% of myopic children did not wear glasses, and 59.4% of myopic children had inaccurate spectacles. The prevention and treatment of myopia are critical. We should focus more on the eyesight health of children in the northwest plateau region to further explore opportunities and methods to prevent and control myopia.