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Prevalence Of Potentially Inappropriate Medication In The Older Adult Population Within Primary Care In Portugal: A Nationwide Cross-Sectional Study

Authors Simões PA, Santiago LM, Maurício K, Simões JA

Received 13 June 2019

Accepted for publication 21 August 2019

Published 19 September 2019 Volume 2019:13 Pages 1569—1576

DOI https://doi.org/10.2147/PPA.S219346

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Cristina Weinberg

Peer reviewer comments 2

Editor who approved publication: Dr Johnny Chen


Pedro Augusto Simões,1,2 Luiz Miguel Santiago,3–5 Katia Maurício,3 José Augusto Simões1,6,7

1Faculty of Health Sciences, University of Beira Interior, Covilhã, Portugal; 2ARS Centro, USF Pulsar, Coimbra, Portugal; 3University of Coimbra, Faculty of Medicine, Coimbra, Portugal; 4University of Coimbra, General Practice/Family Medicine University Clinic of the Faculty of Medicine, Coimbra, Portugal; 5University of Coimbra, CEISUC – Center for Health Studies and Research, Coimbra, Portugal; 6ARS Centro, USF Caminhos Do Cértoma, Mealhada, Portugal; 7University of Porto, CINTESIS – Centre for Research in Health Technologies and Service, Oporto, Portugal

Correspondence: Pedro Augusto Simões
ARS Centro, USF Pulsar, Rua Teófilo Braga, nº 25 5º Dto, Coimbra 3030-076, Portugal
Tel +351 239 968384396
Email pedro.augusto.simoes@ubi.pt

Background: In potentially inappropriate medications harm potentially outweighs benefits. Even appropriately prescribed medications may become inappropriate. They can lead to a high risk of adverse drug reactions, morbidity and mortality. The aim of this study was to determine the prevalence of potentially inappropriate medication in the older adult population attending primary care in Portugal and to identify associated sociodemographic and clinical factors.
Methods: We conducted a cross-sectional, analytical study in primary care centres from the five Portuguese healthcare administrative regions and the two autonomous regions. We used a random sample of 757 older patients provided by the information department of the ministry of health (SPMS) and family doctors from the autonomous regions. Data collection occurred March 2018 and we studied sociodemographic characteristics, clinical profile and medication. We used 2015 Beers Criteria to assess potentially inappropriate medications. Logistic regression analyses were performed to determine associations between potentially inappropriate medications’ prescriptions and other variables.
Results: Potentially inappropriate medication was present in 68.6% and 46.1% of the sample had two or more. The likelihood of having potentially inappropriate medication increased significantly with being female (OR=1.56 [1.05 to 2.31]), number of chronic health problems (OR=1.06 [1.01 to 1.13]), number of pharmacological subclasses (OR=1.40 [1.30 to 1.51]) and number of prescribers (OR=1.34 [1.09 to 1.65]). Proton-pump inhibitors, nonsteroidal anti-inflammatory drugs and benzodiazepines were the most commonly found ones.
Conclusion: Potentially inappropriate medication in older adults was found to be a common occurrence in Portugal. It is important that doctors are aware of this problem, namely in the primary care setting due to the longitudinal care.

Keywords: potentially inappropriate medication, aged, polypharmacy, multimorbidity

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