Back to Journals » International Journal of Chronic Obstructive Pulmonary Disease » Volume 10 » Issue 1

Prevalence of chronic kidney diseases in patients with chronic obstructive pulmonary disease: assessment based on glomerular filtration rate estimated from creatinine and cystatin C levels

Authors Yoshizawa T, Okada K, Furuichi S, Ishiguro T, Yoshizawa A, Akahoshi T, Gon Y, Akashiba T, Hosokawa Y, Hashimoto S

Received 9 January 2015

Accepted for publication 11 May 2015

Published 6 July 2015 Volume 2015:10(1) Pages 1283—1289

DOI https://doi.org/10.2147/COPD.S80673

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Editor who approved publication: Dr Richard Russell

Takayuki Yoshizawa,1,2 Kazuyoshi Okada,3 Sachiko Furuichi,1,2 Toshihiko Ishiguro,1 Akitaka Yoshizawa,1 Toshiki Akahoshi,2 Yasuhiro Gon,2 Tsuneto Akashiba,2 Yoshifumi Hosokawa,1,2 Shu Hashimoto2

1Department of Internal Medicine, Kanamecho Hospital, Toshima-ku, 2Division of Respiratory Medicine, Department of Internal Medicine, 3Division of Nephrology, Hypertension and Endocrinology, Department of Medicine, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan

Background: Cardiovascular diseases, osteoporosis, and depression are identified comorbidities of chronic obstructive pulmonary disease (COPD), but there have been few reports of chronic kidney disease (CKD) as a comorbidity of COPD. The objective of this study was to investigate the prevalence of CKD in COPD patients using estimated glomerular filtration rate (eGFR) based on creatinine (Cr) and cystatin C (Cys) levels.
Methods: The prevalence of CKD and the values of various CKD-related parameters were compared between 108 stable COPD outpatients (COPD group) and a non-COPD control group consisting of 73 patients aged 60 years or more without a history of COPD or kidney disease. CKD was defined as an eGFR less than 60 mL/min/1.73 m2.
Results: The Cr level was significantly higher in the COPD group, but eGFR based on serum Cr (eGFRCr) was not significantly different between the two groups (73.3±25.3 vs 79.7±15.5 mL/min/1.73 m2). The Cys level was significantly higher and eGFR based on serum Cys (eGFRCys) was significantly lower in the COPD group (60.0±19.4 vs 74.0±13.5 mL/min/1.73 m2, P<0.0001). The prevalence of CKD evaluated based on eGFRCr was 31% in the COPD group and 8% in the non-COPD group with an odds ratio of 4.91 (95% confidence interval, 1.94–12.46, P=0.0008), whereas the evaluated prevalence based on eGFRCys was 53% in the COPD group and 15% in the non-COPD group with an odds ratio of 6.30 (95% confidence interval, 2.99–13.26, P<0.0001), demonstrating a higher prevalence of CKD when based on eGFRCys rather than on eGFRCr.
Conclusion: CKD is a comorbidity that occurs frequently in COPD patients, and we believe that renal function in Japanese COPD patients should preferably be evaluated based not only on Cr but on Cr in combination with Cys.

Keywords: CKD, comorbidity, COPD, eGFR
 

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]

 

Readers of this article also read:

Personalized pulmonary rehabilitation and occupational therapy based on cardiopulmonary exercise testing for patients with advanced chronic obstructive pulmonary disease

Maekura R, Hiraga T, Miki K, Kitada S, Miki M, Yoshimura K, Yamamoto H, Kawabe T, Mori M

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1787-1800

Published Date: 3 September 2015

C-reactive protein levels in stable COPD patients: a case-control study

Silva DR, Gazzana MB, Knorst MM

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1719-1725

Published Date: 31 August 2015

Modified Medical Research Council scale vs Baseline Dyspnea Index to evaluate dyspnea in chronic obstructive pulmonary disease

Perez T, Burgel PR, Paillasseur JL, Caillaud D, Deslée G, Chanez P, Roche N

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1663-1672

Published Date: 18 August 2015

VitalQPlus: a potential screening tool for early diagnosis of COPD

Sui CF, Ming LC, Neoh CF, Ibrahim B

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1613-1622

Published Date: 11 August 2015

Safety of inhaled glycopyrronium in patients with COPD: a comprehensive analysis of clinical studies and post-marketing data

D’Urzo AD, Kerwin EM, Chapman KR, Decramer M, DiGiovanni R, D’Andrea P, Hu H, Goyal P, Altman P

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1599-1612

Published Date: 11 August 2015

Comorbidities in obstructive lung disease in Korea: data from the fourth and fifth Korean National Health and Nutrition Examination Survey

Park HJ, Leem AY, Lee SH, Song JH, Park MS, Kim YS, Kim SK, Chang J, Chung KS

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1571-1582

Published Date: 7 August 2015

Relation between systemic inflammatory markers, peripheral muscle mass, and strength in limb muscles in stable COPD patients

Ferrari R, Caram LMO, Faganello MM, Sanchez FF, Tanni SE, Godoy I

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1553-1558

Published Date: 6 August 2015

Palliative care in COPD: an unmet area for quality improvement

Vermylen JH, Szmuilowicz E, Kalhan R

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1543-1551

Published Date: 6 August 2015

Influence of pulmonary emphysema on COPD assessment test-oriented categorization in GOLD document

Suzuki T, Tada Y, Kawata N, Ikari J, Kasahara Y, Sakurai Y, Iesato K, Nishimura R, West J, Tatsumi K

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:1199-1205

Published Date: 19 June 2015