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Prevalence of Asymptomatic Bacteriuria, Associated Factors and Antimicrobial Susceptibility Profile of Bacteria Among Pregnant Women Attending Saint Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia

Authors Wabe YA, Reda DY, Abreham ET, Gobene DB, Ali MM

Received 23 July 2020

Accepted for publication 14 September 2020

Published 29 September 2020 Volume 2020:16 Pages 923—932

DOI https://doi.org/10.2147/TCRM.S267101

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 4

Editor who approved publication: Professor Garry Walsh


Yasin Awol Wabe,1 Dawit Yihdego Reda,2 Estifanos Tsige Abreham,3 Degeuf Beyene Gobene,3 Musa Mohammed Ali2

1Werabe Comprehensive Specialized Hospital, Worabe, Ethiopia; 2Hawassa University, School of Medical Laboratory Science, Hawassa, Ethiopia; 3Ethiopian Public Health Institute, Addis Ababa, Ethiopia

Correspondence: Yasin Awol Wabe Email awolyasin30@gmail.com

Introduction: Asymptomatic bacteriuria (ASB) is the presence of bacteria in significant quantity in the absence of signs and symptoms of urinary tract infection (UTI). ASB, if it occurs during pregnancy, can cause serious complications both among fetus and pregnant women.
Objective: The aim of this study was to determine the prevalence of ASB, its associated factors, and antimicrobial susceptibility profile of bacterial isolates among pregnant women.
Methods: A cross-sectional study was conducted from July to September 2019 among 290 pregnant women at Saint Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia. Clean-catch midstream urine specimens were collected using sterile containers and cultured on MacConkey agar and sheep blood agar to isolate bacteria. Socio-demographic and obstetric data were collected using a structured questionnaire. Data were analyzed by SPSS version 22. The association between ASB and risk factors was assessed using logistic regressions. A p-value ≤ 0.05 was considered as a cut point to determine the significant association.
Results: From 290 study participants, 16.9% with 95 CI [13.1, 21.5] were positive for ASB. The predominant bacteria were Escherichia coli (43%) and Staphylococcus aureus (20%). Majority of E. coli (91.0%) were susceptible to nitrofurantoin and gentamycin; most of them were resistant to amoxicillin (86.4%) and cotrimoxazole (77.7%). The proportion of multi-drug resistance (MDR) isolates was 57.1%. Previous infection with UTI, previous history of catheterization, and natural abortion were significantly associated with ASB.
Conclusion: In the study area, ASB is prevalent in the study area indicating the importance of screening of ASB and possible treatment to prevent its consequences.

Keywords: asymptomatic bacteriuria, antibiotic susceptibility, pregnant woman, Addis Ababa, Ethiopia

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