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Prevalence, impact, and management of depression and anxiety in patients with Parkinson’s disease

Authors Renfroe J, Turner T, Hinson V

Received 7 November 2015

Accepted for publication 11 January 2016

Published 1 April 2016 Volume 2016:6 Pages 15—22

DOI https://doi.org/10.2147/JPRLS.S83165

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Qian Wu

Peer reviewer comments 4

Editor who approved publication: Dr Peter Hedera


Jenna B Renfroe,1 Travis H Turner,2,3 Vanessa K Hinson1,4

1Department of Neurology, Medical University of South Carolina, Charleston, SC, USA; 2Mental Health Service, Ralph H. Johnson VA Medical Centre, Charleston, SC, USA; 3Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA; 4Neurology Service, Ralph H. Johnson VA Medical Centre, Charleston, SC, USA

Abstract: Individuals with Parkinson’s disease (PD) exhibit higher rates of depression and anxiety than the general and other medically disabled populations. Evidence suggests that mood and anxiety symptoms are related to disease pathology. Rates of depression and anxiety in PD vary depending on how these symptoms are measured, but they are estimated to occur in up to 40% of patients. These conditions have adverse effects on patient and caregivers’ quality of life, level of disability, and mortality, with several studies suggesting greater contribution than motor symptom severity. Pharmacological and psychotherapeutic interventions, particularly in combination, have demonstrated efficacy in treating depression and anxiety in PD. However, additional randomized controlled trials are needed to better delineate when and how to best treat these disabling symptoms.

Keywords: Parkinson’s disease, depression, anxiety, prevalence, treatment

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