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Prevalence and Risk Factors of Osteoporosis in Chinese Postmenopausal Women Awaiting Total Knee Arthroplasty

Authors Tao Y, Tang S, Huang X, Wang H, Zhou A, Zhang J

Received 17 December 2020

Accepted for publication 10 February 2021

Published 26 February 2021 Volume 2021:16 Pages 379—387

DOI https://doi.org/10.2147/CIA.S297947

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 4

Editor who approved publication: Prof. Dr. Zhi-Ying Wu


Yuzhang Tao,1 Siying Tang,2 Xiao Huang,1 Hongwei Wang,1 Aiguo Zhou,1 Jian Zhang1

1Department of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, People’s Republic of China; 2Department of Clinical Nutrition, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, People’s Republic of China

Correspondence: Jian Zhang
Department of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, People’s Republic of China
Email [email protected]

Background: Total knee arthroplasty (TKA) complications associated with low bone quality are challenging for orthopaedic surgeons to treat, but little is known about bone quality in Chinese postmenopausal women awaiting TKA. This study investigated the incidence of osteoporosis (OP) and explored the preoperative risk factors for OP in this population.
Methods: We retrospectively reviewed the data of Chinese postmenopausal women who were indicated for TKA between May 2017 and June 2020. The bone mineral density (BMD) of the hip and lumbar spine and multiple preoperative parameters were collected and analyzed. Binary logistic regression analysis was performed to identify independent risk factors for OP in this population.
Results: A total of 204 postmenopausal women with advanced knee OA were included in the study (age: 69.7± 8.5 years; body mass index [BMI]: 25.5± 4.0 kg/m2). The OP prevalence among all participants was 59.8%, and the patients aged 60– 80 years had a significantly lower BMD than did the age/ethnicity-adjusted population. An age ≥ 60 years, a BMI< 25, and the presence of a varus knee deformity were independent risk factors for preoperative OP in the postmenopausal women awaiting TKA.
Conclusion: The prevalence of OP in Chinese postmenopausal women awaiting TKA is higher than that in the age/ethnicity-adjusted normal population. An age ≥ 60 years, a BMI< 25, and the presence of a varus knee deformity are independent risk factors that can be used to predict preoperative OP in this population.

Keywords: osteoporosis, postmenopausal women, total knee arthroplasty, Chinese, bone mineral density

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