Back to Browse Journals » Vascular Health and Risk Management » Volume 8

Prevalence and risk factors associated with peripheral artery disease in elderly patients undergoing peritoneal dialysis

Authors Kuang DW, Li CL, Kuok UI, Cheung K, Lio WI, Xin J

Received 14 August 2012

Accepted for publication 4 September 2012

Published 19 October 2012 Volume 2012:8 Pages 581—586


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Ding-Wei Kuang,1,2,* Chiu-Leong Li,1,* Un-I Kuok,1 Kin Cheung,1 Weng-In Lio,1 Jing Xin1,2

Department of Nephrology, Centro Hospitalar Conde de São Januário, Macao, China; 2Department of Nephrology, Huashan Hospital, Shanghai, China

*These authors contributed equally to this work

Background: Rapid growth of the elderly peritoneal dialysis (PD) population is posing a special challenge for renal teams. Peripheral artery disease (PAD) has been reported to be an independent predictor of cardiovascular and all-cause mortality in hemodialysis patients. However, the prevalence and associated risk factors for PAD in elderly PD patients have not yet been fully investigated.
Methods: A total of 69 elderly PD patients were included in the present study. PAD was defined as either an ankle-brachial index < 0.9 or a history of intermittent claudication, lower-limb amputation, foot ulcers, or gangrene. On enrollment, clinical and biochemical characteristics were collected.
Results: The overall prevalence of PAD was 31.9%. Compared with non-PAD patients, PAD patients were significantly older and more likely to be female and have longer PD duration and lower diastolic blood pressure (P < 0.001, = 0.002, 0.018, and 0.007, respectively). Serum albumin level (P < 0.001) and residual renal Kt/V value (P < 0.001) were significantly lower, but the serum C-reactive protein level (P = 0.005) was significantly higher, in PAD patients compared with non-PAD patients. Logistic regression analysis showed that serum albumin level (odds ratio = 1.485, P = 0.040) and residual renal Kt/V value (odds ratio = 1.725, P = 0.016) were independently associated with PAD.
Conclusion: A high prevalence of PAD appeared among elderly PD patients in Macao. Serum albumin level and residual renal Kt/V value were independently related to PAD.

Keywords: ankle-brachial index, atherosclerosis, elderly, peripheral artery disease, peritoneal dialysis

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF] View Full Text [HTML] 


Readers of this article also read:

Development of a liposome-based formulation for vitamin K1 nebulization on the skin

Campani V, Marchese D, Pitaro MT, Pitaro M, Grieco P, De Rosa G

International Journal of Nanomedicine 2014, 9:1823-1832

Published Date: 10 April 2014

Genetically engineered nanocarriers for drug delivery

Shi P, Gustafson JA, MacKay JA

International Journal of Nanomedicine 2014, 9:1617-1626

Published Date: 26 March 2014

Tissue inhibitor of matrix metalloproteinases-1 loaded poly(lactic-co-glycolic acid) nanoparticles for delivery across the blood–brain barrier

Chaturvedi M, Molino Y, Sreedhar B, Khrestchatisky M, Kaczmarek L

International Journal of Nanomedicine 2014, 9:575-588

Published Date: 20 January 2014


Parizek M, Douglas TEL, Novotna K, Kromka A, Brady MA, Renzing A, Voss E, Jarosova M, Palatinus L, Tesarek P, Ryparova P, Lisa V, dos Santos AM, Bacakova L

International Journal of Nanomedicine 2012, 7:5873-5874

Published Date: 26 November 2012

Gemcitabine-loaded liposomes: rationale, potentialities and future perspectives

Federico C, Morittu VM, Britti D, Trapasso E, Cosco D

International Journal of Nanomedicine 2012, 7:5423-5436

Published Date: 1 November 2012

Rivaroxaban in atrial fibrillation

Giorgi MA, Miguel LS

Vascular Health and Risk Management 2012, 8:525-531

Published Date: 30 August 2012

Titanium dioxide induces apoptotic cell death through reactive oxygen species-mediated Fas upregulation and Bax activation

Yoo KC, Yoon CH, Kwon DW, Hyun KH, Woo SJ, Kim RK, Lim EJ, Suh YJ, Kim MJ, Yoon TH, Lee SJ

International Journal of Nanomedicine 2012, 7:1203-1214

Published Date: 5 March 2012

A self-assembling peptide RADA16-I integrated with spider fibroin uncrystalline motifs

Sun L, Zhao X

International Journal of Nanomedicine 2012, 7:571-580

Published Date: 2 February 2012

Nanomedicine in pulmonary delivery

Heidi M Mansour, Yun-Seok Rhee, Xiao Wu

International Journal of Nanomedicine 2009, 4:299-319

Published Date: 7 December 2009

Nanofibers and their applications in tissue engineering

Rajesh Vasita, Dhirendra S Katti

International Journal of Nanomedicine 2006, 1:15-30

Published Date: 15 March 2006