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Preserving fertility in young patients with lymphoma: an overview

Authors Patel B, Rossi B

Received 1 September 2014

Accepted for publication 28 October 2014

Published 18 December 2014 Volume 2015:5 Pages 1—15

DOI https://doi.org/10.2147/BLCTT.S47236

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Professor David Dingli


Bansari Patel, Brooke V Rossi

Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Case Western Reserve University, Cleveland, OH, USA


Abstract: Fertility preservation affords patients the ability to reproduce after the initial diagnosis and management of such malignancies as Hodgkin's and non-Hodgkin's lymphoma. Certain chemotherapy regimens and pelvic radiotherapy confer a high-risk of subsequent gonadal compromise in both males and females. Fortunately, early counseling and initiation of fertility-preservation strategies promptly after diagnosis enable patients to maintain hope for future reproduction. Well-established methods for fertility preservation include embryo and oocyte cryopreservation in females and sperm cryopreservation in males. These methods enable patients to utilize assisted reproductive technologies, including in vitro fertilization, at the time of desired childbearing in order to ensure genetic offspring. As most of these modalities are not feasible in some patient populations, including prepubescent patients, newer methods of fertility preservation must be created to ensure the ability to produce genetic offspring in lymphoma patients. This review provides insights into the impact of gonadotoxic treatment on ovarian and testicular function, and highlights current modalities in fertility preservation in both males and females.

Keywords: fertility preservation, lymphoma, ART, egg freezing


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