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Preparation, characterization, and in vitro osteoblast functions of a nano-hydroxyapatite/polyetheretherketone biocomposite as orthopedic implant material

Authors Ma R, Tang SC, Tan HL, Lin WT, Wang YG, Wei J, Zhao LM, Tang TT

Received 7 May 2014

Accepted for publication 3 June 2014

Published 18 August 2014 Volume 2014:9(1) Pages 3949—3961

DOI https://doi.org/10.2147/IJN.S67358

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Rui Ma,1 Songchao Tang,2 Honglue Tan,1 Wentao Lin,1 Yugang Wang,1 Jie Wei,2 Liming Zhao,2 Tingting Tang1

1Shanghai Key Laboratory of Orthopedic Implants, Department of Orthopedic Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, 2Key Laboratory for Ultrafine Materials of Ministry of Education and The State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, People’s Republic of China

Abstract: A bioactive composite was prepared by incorporating 40 wt% nano-­hydroxyapatite (nHA) into polyetheretherketone (PEEK) through a process of compounding, injection, and molding. The mechanical and surface properties of the nHA/PEEK composite were characterized, and the in vitro osteoblast functions in the composite were investigated. The mechanical properties (elastic modulus and compressive strength) of the nHA/PEEK composite increased significantly, while the tensile strength decreased slightly as compared with PEEK. Further, the addition of nHA into PEEK increased the surface roughness and hydrophilicity of the nHA/PEEK composite. In cell tests, compared with PEEK and ultra-high-molecular-weight polyethylene, it was found that the nHA/PEEK composite could promote the functions of MC3T3-E1 cells, including cell attachment, spreading, proliferation, alkaline phosphatase activity, calcium nodule formation, and expression of osteogenic differentiation-related genes. Incorporation of nHA into PEEK greatly improved the bioperformance of PEEK. The nHA/PEEK composite might be a promising orthopedic implant material.

Keywords: polyetheretherketone, nano-hydroxyapatite, biocomposite, osteoblast functions, orthopedic implant material

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