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Preliminary study of CT in combination with MRI perfusion imaging to assess hemodynamic changes during angiogenesis in a rabbit model of lung cancer
Authors Zhang Q, Shi, Liu, Zhang, Zhang W
Received 19 March 2013
Accepted for publication 7 May 2013
Published 17 June 2013 Volume 2013:6 Pages 685—692
DOI https://doi.org/10.2147/OTT.S45403
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Qiang Zhang,1 Baoqi Shi,1 Zhaoxin Liu,1 Mingmin Zhang,1 Weijing Zhang2
1Radiology Department, Baotou Cancer Hospital, Inner Mongolia Autonomous Region, 2Department of Mathematics, College of Science, Beijing Institute of Technology, Beijing, People's Republic of China
Background: This study used CT (computed tomography) and magnetic resonance imaging (MRI) to identify correlations between perfusion parameters for squamous cell lung carcinoma and tumor angiogenesis in a rabbit model of VX2 lung cancer.
Methods: VX2 tumors were implanted in the lungs of 35 New Zealand White rabbits. CT and MRI perfusion scanning were performed on days 14, 17, 21, 25, and 28 after tumor implantation. CT perfusion parameters were perfusion, peak enhanced increment, transit time peak, and blood volume, and MRI perfusion parameters were wash in rate, wash out rate, maximum enhancement rate, and transit time peak. CT and MRI perfusion parameters were obtained at the tumor rim, in the tumor tissue, and in the muscle tissue surrounding the tumor.
Results: On CT perfusion imaging, t values for perfusion, peak enhanced increment, and blood volume (tumor rim versus muscle) were 16.31, 11.79, and 5.21, respectively (P < 0.01); t values for perfusion, peak enhanced increment, and blood volume (tumor versus muscle) were 9.87, 4.09, and 5.35, respectively (P < 0.01); and t values for transit time peak were 1.52 (tumor rim versus muscle) and 1.29 (tumor versus muscle), respectively (P > 0.05). On MRI perfusion imaging, t values for wash in rate, wash out rate, and maximum enhancement rate (tumor rim versus muscle) were 18.14, 8.79, and 6.02, respectively (P < 0.01); t values for muscle wash in rate, wash out rate, and maximum enhancement rate (tumor versus muscle) were 9.45, 8.23, and 4.21, respectively (P < 0.01); and t values for transit time peak were 1.21 (tumor rim versus muscle) and 1.05 (tumor versus muscle), respectively (P > 0.05).
Conclusion: A combination of CT and MRI perfusion imaging demonstrated hemodynamic changes in a rabbit model of VX2 lung cancer, and provides a theoretical foundation for treatment of human squamous cell lung carcinoma.
Keywords: perfusion imaging, rabbits, animal model, lung, squamous carcinoma cell
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