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Pregnancy-induced growth of a spinal hemangioblastoma: presumed mechanisms and their implications for therapeutic approaches

Authors da Mota Silveira Rodrigues A, Simões Fernandes F, Farage L, Almeida Prado Franceschi LE, Brito Vogt MDF, Zaconeta AM

Received 24 February 2018

Accepted for publication 25 April 2018

Published 21 June 2018 Volume 2018:10 Pages 325—328


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Professor Everett F Magann

Amanda da Mota Silveira Rodrigues,1 Fábio Simões Fernandes,2 Luciano Farage,3 Luiz Eduardo Almeida Prado Franceschi,4 Maria de Fátima Brito Vogt,1 Alberto Moreno Zaconeta1

1Department of Gynecology and Obstetrics, University Hospital of Brasilia, University of Brasília, Brasília, Brazil; 2Department of Neurosurgery, University Hospital of Brasilia, Brasília, Brazil; 3Faculty of Medicine, University of Brasília, Brasília, Brazil; 4Diagnose Pathology and Cytology Laboratory, Brasília, Brazi

Abstract: Hemangioblastomas are benign tumors of the central nervous system (CNS) that may occur either sporadically or as part of von Hippel–Lindau (VHL) disease, in which they coexist with a series of other tumors outside the CNS. Because of their low mitosis rate, hemangioblastomas usually have slow-growing and late manifestations, but may cause sudden neurological symptoms if tumor hemorrhage occurs. Few studies have evaluated the impact of pregnancy on the evolution of hemangioblastomas. Some authors have reported tumor growth in women with VHL disease, but no such association was observed by others. The influence of pregnancy on sporadic hemangioblastomas remains largely unexplored. We report here the case of a pregnant woman whose first manifestation of sporadic spinal hemangioblastoma was life-threatening, rapidly progressive dysautonomia. In addition, we discuss the role of pregnancy in the triggering of symptoms, as well as the possibility of medically indicated delivery for the management of these tumors.

Keywords: spinal hemangioblastoma, syringomyelia, pregnancy tumors, symptomatic hemangioblastoma, bulbomedullary edema, pregnancy-related hemangioblastoma

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