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Preemptive analgesia after lumbar spine surgery by pregabalin and celecoxib: a prospective study

Authors Kien NT, Geiger P, Van Chuong H, Cuong NM, Van Dinh N, Pho DC, Anh VT, Giang NT

Received 21 January 2019

Accepted for publication 12 June 2019

Published 3 July 2019 Volume 2019:13 Pages 2145—2152

DOI https://doi.org/10.2147/DDDT.S202410

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 3

Editor who approved publication: Dr Yan Zhu


Nguyen Trung Kien,1 Phillip Geiger,2 Hoang Van Chuong,1 Nguyen Manh Cuong,1 Ngo Van Dinh,1 Dinh Cong Pho,3 Vu The Anh,1 Nguyen Truong Giang4

1Department of Anesthesia and Pain Medicine, Military Hospital 103, Vietnam Military Medical University, Hanoi, Vietnam; 2Department of Anesthesiology, Perioperative, and Pain Medicine, Naval Medical Center Portsmouth, Portsmouth, VA, USA; 3Faculty of Medicine, Vietnam Military Medical University, Hanoi, Vietnam; 4Department of Cardiothoracic Surgery, Military Hospital 103, Vietnam Military Medical University, Hanoi, Vietnam

Objective: To evaluate the preemptive analgesic effect of combination pregabalin with celecoxib for lumbar spine surgery.
Methods: A prospective, randomized study was conducted among 60 lumbar spine surgery patients and divided into two groups. Postoperative pain relief was achieved with intravenous patient-controlled analgesia with morphine. The preemptive analgesia group received oral pregabalin (150 mg) and celecoxib (200 mg) 2 hrs before surgery, and the control group received a placebo. Pain was assessed by visual analogue scale (VAS). Side effects and morphine consumption were monitored until 48 hrs after surgery.
Results: VAS score at rest and during movement was statistically significantly lower in the preemptive analgesia group at most time points (p<0.05). Morphine consumption was significantly lower in the preemptive analgesia group compared with control group in the 24 first hours (29.03±4.38 mg vs 24.43±4.94) and 48 hrs (52.23±9.57 mg vs 44.20±10.21 mg), p<0.05. Hemodynamics, respiratory rate, and SpO2 were similar for both groups. The sedation score was only statistically significant at H8 time point. The incidence of nausea/vomiting in the preemptive group did not statistically differ from the control group.
Conclusion: Preoperative administration of pregabalin combined with celecoxib had a good preemptive analgesia effect and reduced intravenous morphine consumption after lumbar spine surgery. Side effects were mild and transient.

Keywords: preemptive analgesia, pregabalin, celecoxib, lumbar spine surgery

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