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Predictors of medication nonadherence in patients with systemic lupus erythematosus in Sichuan: a cross-sectional study

Authors Xie X, Yang H, Nie A, Chen H, Li J

Received 30 March 2018

Accepted for publication 26 June 2018

Published 21 August 2018 Volume 2018:12 Pages 1505—1511

DOI https://doi.org/10.2147/PPA.S169776

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 3

Editor who approved publication: Dr Naifeng Liu


Xia Xie, Hui Yang, Anliu Nie, Hong Chen,* Jiping Li*

West China School of Nursing and Department of Nursing, West China Hospital, Sichuan University, Chengdu, China

*These authors contributed equally to this work

Purpose: The aim of this study was to determine the prevalence and predictors of medication nonadherence among patients with systemic lupus erythematosus (SLE) in Sichuan.
Patients and methods: A cross-sectional investigation was performed. Participants were recruited by consecutive sampling from the Rheumatic Clinic of a university hospital between June and September 2016. Patients’ self-reported medication adherence was assessed by the eight-item Morisky Medication Adherence Scale. Additional surveys included patients’ demographics, and clinical and treatment characteristics. Logistic regression analysis was used to identify the predictors of medication nonadherence.
Results: A total of 140 patients were included in analysis. The percentage of patients classified as nonadherent to medication was 75%. Low education, rural residency, childlessness, limited comprehension of medication instructions, side effects experienced, dissatisfaction with treatment and better physical health were associated with an increased risk of nonadherence.
Conclusion: This study demonstrated a high prevalence of medication nonadherence among SLE patients in Sichuan, and factors associated with the nonadherence are multifaceted. Interventions for these factors, such as appropriate adjustment of the service resources for patients with rheumatic disease in rural communities and improved communication between the health care providers and the patients, may contribute to improve the medication adherence of this cohort.

Keywords: systemic lupus erythematosus, medication management, adherence, predictors

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