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Pre-Exposure Prophylaxis for COVID-19 in Pregnant Women

Authors Fesler MC, Stricker RB

Received 3 December 2020

Accepted for publication 13 January 2021

Published 26 January 2021 Volume 2021:14 Pages 279—284


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Scott Fraser

Melissa C Fesler,1,2 Raphael B Stricker1,2

1Alan E. Beer Medical Center for Reproductive Immunology, Los Gatos, CA, USA; 2Union Square Medical Associates, San Francisco, CA, USA

Correspondence: Raphael B Stricker
Union Square Medical Associates, 450 Sutter Street, Suite 1504, San Francisco, CA 94108, USA
Tel +1 415-399-1035

Abstract: Pregnant women are at higher risk for developing severe complications of COVID-19 including preterm delivery, respiratory failure, and death. Although vaccines to prevent COVID-19 are being developed, pregnant women are not included in the current COVID-19 vaccine trials and initially this population may not be eligible for COVID-19 vaccines due to lack of safety testing in pregnancy. As an alternate approach, we discuss the concept of pre-exposure prophylaxis (PrEP) using medications that are approved for use in pregnant women to prevent gestational problems and severe illness in this high-risk population. In particular, the use of hydroxychloroquine PrEP affords a safe and readily available means to avoid COVID-19 complications in pregnancy.

Keywords: COVID-19, SARS-CoV-2, pregnancy, pre-exposure prophylaxis, hydroxychloroquine, vaccine

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