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Potential roles of GPR120 and its agonists in the management of diabetes

Authors Zhang D, Leung PS

Received 31 March 2014

Accepted for publication 14 May 2014

Published 29 July 2014 Volume 2014:8 Pages 1013—1027

DOI https://doi.org/10.2147/DDDT.S53892

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Dan Zhang, Po Sing Leung

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong

Abstract: Free fatty acids (FFAs) serve not only as nutrients that provide energy but also as extracellular signaling molecules that manipulate intracellular physiological events through FFA receptors (FFARs) such as FFAR4. FFAR4 is also known as G-protein coupled receptor 120 (GPR120). The main role of GPR120 is to elicit FFA regulation on metabolism homeostasis. GPR120 agonism correlates with prevention of the occurrence and development of metabolic disorders such as obesity and diabetes. GPR120 activation directly or indirectly inhibits inflammation, modulates hormone secretion from the gastrointestinal tract and pancreas, and regulates lipid and/or glucose metabolism in adipose, liver, and muscle tissues, which may help prevent obesity and diabetes. This review summarizes recent advances in physiological roles of GPR120 in preventing insulin resistance and protecting pancreatic islet function, and examines how resident GPR120 in the pancreas may be involved in modulating pancreatic islet function.

Keywords: fatty acid, G protein-coupled receptors, inflammation, pancreas, obesity

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