Back to Journals » International Journal of Women's Health » Volume 4

Potential role of tenofovir vaginal gel for reduction of risk of herpes simplex virus in females

Authors Tan D

Received 19 May 2012

Accepted for publication 28 June 2012

Published 19 July 2012 Volume 2012:4 Pages 341—350

DOI https://doi.org/10.2147/IJWH.S27601

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2


DHS Tan
Divisions of Infectious Diseases, St Michael's Hospital, University Health Network, and University of Toronto, Toronto, Canada

Abstract: A surprising result of the groundbreaking CAPRISA-004 trial, which demonstrated the efficacy of vaginal tenofovir 1% gel in reducing the risk of human immunodeficiency virus (HIV)-1 infection by 39% in heterosexual women, was the added benefit of this microbicide in reducing acquisition of herpes simplex virus type 2 (HSV-2) by 51%. HSV-2 is the most common cause of genital ulcer disease worldwide, and is responsible for considerable morbidity among women and neonates. The virus is further implicated in increasing the risk of both HIV acquisition and transmission, and may have additional adverse consequences in HIV-coinfected persons, making HSV-2 prevention an important clinical and public health objective. While tenofovir had not previously been widely considered to be an anti-herpes drug, in vitro activity against HSV is well documented, raising interest in potential future applications of tenofovir and its prodrugs in HSV-2 control. This article reviews the currently available data for tenofovir as an anti-herpes agent, as well as unanswered questions about delivery systems, drug formulation, rectal administration, drug resistance, and clinical applications.

Keywords: tenofovir, herpes simplex virus type 2, microbicide, CAPRISA-004

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]