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Potential clinical application of lncRNAs in non-small cell lung cancer

Authors Lu T, Wang Y, Chen D, Liu J, Jiao W

Received 27 June 2018

Accepted for publication 12 October 2018

Published 13 November 2018 Volume 2018:11 Pages 8045—8052

DOI https://doi.org/10.2147/OTT.S178431

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 3

Editor who approved publication: Dr Sanjeev Srivastava


Tong Lu,1 Yuanyong Wang,1 Di Chen,2 Jia Liu,3 Wenjie Jiao1

1Department of Thoracic Surgery, Affiliated Hospital of Qingdao University, Qingdao, China; 2Department of Gastroenterology, Affiliated Hospital of Qingdao University, Qingdao, China; 3School of Pharmacy, Qingdao University, Qingdao, China

Abstract: Lung cancer has been identified as one of the most prevalent and deadly tumors worldwide. In recent years, lncRNAs have been demonstrated to play a significant role in the development of lung cancer. Specifically, lncRNAs act as a regulator of cancer-critical genes, and they regulate the biological behavior of tumors at the transcriptional and posttranscriptional levels. Recent studies have shown that lncRNAs possess great potential in the treatment of non-small cell lung cancer patients because of their roles in diverse cellular processes, such as proliferation, metastasis, stem cell maintenance, and epithelial to mesenchymal transition, and they serve as signaling biomarkers. Compared to other invasive diagnostic methods, detection of lncRNAs may become a very useful noninvasive methodology. Moreover, lncRNAs can serve as potential therapeutic targets in non-small cell lung cancer due to their roles in regulating many signaling pathways associated with lung carcinoma. In this review, we discuss the roles and expression profile of lncRNAs. We also discuss the promising application of lncRNAs as predictors of clinical diagnosis, prognosis, and as potential therapeutic targets, aiming to demonstrate their practical value for clinical treatment.

Keywords: biomarker, lncRNA, diagnosis, prognosis, therapy, NSCLC

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