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Possibility of using superoxide dismutase and glutathione peroxidase as endometriosis biomarkers

Authors Ekarattanawong S, Tanprasertkul C, Somprasit C, Chamod P, Tiengtip R, Bhamarapravatana K, Suwannarurk K

Received 3 May 2017

Accepted for publication 30 August 2017

Published 27 September 2017 Volume 2017:9 Pages 711—716

DOI https://doi.org/10.2147/IJWH.S141021

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Professor Everett F Magann


Sophapun Ekarattanawong,1 Chamnan Tanprasertkul,2 Charintip Somprasit,2 Pholasit Chamod,1 Rattana Tiengtip,1 Kornkarn Bhamarapravatana,1 Komsun Suwannarurk2

1Department of Preclinical Science, 2Department of Obstetrics and Gynaecology, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand

Objective: To study the possibility of using superoxide dismutase (SOD) and glutathione peroxidase (GPx) as combined preoperative biomarkers for endometriosis.
Participants and methods: Female patients aged between 18 and 45 years old who came to the Gynecology outpatient clinic, Thammasat University Hospital, during September 2013–2016 with the complaint of gynecologic symptoms suspected of endometriosis, and who were positively diagnosed with endometriosis, were included in this study. All patients underwent conservative laparoscopic ovarian cystectomy with histopathological report. The control group consisted of healthy females of reproductive age who came to the outpatient clinic. The plasma SOD and GPx were measured from blood samples with commercial kits. A receiver operating characteristic curve was generated for plasma activity of SOD, GPx, and combined tests. The cutoff values were selected at the most appropriate sensitivity and specificity.
Result: All 36 cases were included in this study. Mean ages of patients in the patient and control groups were 33.1 and 28.6 years old, respectively. SOD and GPx activities of disease and control group were 6.15 and 8.11, 463.9 and 472.34 nmole/min/mL unit, respectively. The sensitivity and 1–specificity of the combined test were calculated at 0.78, with sensitivity, specificity, accuracy, positive predictive value, and negative predictive value being 68.75, 80.77, 76.50, 69.23, and 80.33, respectively.
Conclusion: A combination testing of SOD and GPx can possibly be used as preoperative biomarker for endometriosis.

Keywords: superoxide dismutase, SOD, glutathione peroxidase, GPx, endometriosis, laparoscopy, endometriosis biomarker

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