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Porcine dermis implants in soft-tissue reconstruction: current status

Authors Smart N, Bryan N, Hunt J, Daniels I

Received 2 December 2013

Accepted for publication 8 January 2014

Published 10 March 2014 Volume 2014:8 Pages 83—90

DOI https://doi.org/10.2147/BTT.S46469

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Neil J Smart,1 Nicholas Bryan,2 John A Hunt,2 Ian R Daniels1

1Exeter Surgical Health Services Research Unit, Royal Devon and Exeter Hospital, Exeter, UK; 2Clinical Engineering (UKCTE), The Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK

Abstract: Soft-tissue reconstruction for a variety of surgical conditions, such as abdominal wall hernia or pelvic organ prolapse, remains a challenge. There are numerous meshes available that may be simply categorized as either synthetic or biologic. Within biologic meshes, porcine dermal meshes have come to dominate the market. This review examines the current evidence for their use and the limitations of knowledge. Although there is increasing evidence to support their safety, long-term follow-up studies that support their efficacy are lacking. Numerous clinical trials that remain ongoing may help elucidate their precise role in soft-tissue reconstruction.

Keywords: hernia, mesh, xenograft, biologic

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