Back to Journals » International Journal of Nanomedicine » Volume 6

Polyurethane/fluor-hydroxyapatite nanocomposite scaffolds for bone tissue engineering. Part I: morphological, physical, and mechanical characterization

Authors Asefnejad A, Behnamghader A, Khorasani MT, Farsadzadeh B

Published 6 January 2011 Volume 2011:6 Pages 93—100


Review by Single-blind

Peer reviewer comments 3

Azadeh Asefnejad1, Aliasghar Behnamghader2, Mohammad Taghi Khorasani3, Babak Farsadzadeh1
1Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran; 2Materials and Energy Research Center, Tehran, Iran; 3Iran Polymer and Petrochemical Institute, Tehran, Iran

Abstract: In this study, new nano-fluor-hydroxyapatite (nFHA)/polyurethane composite scaffolds were fabricated for potential use in bone tissue engineering. Polyester urethane samples were synthesized from polycaprolactone, hexamethylene diisocyanate, and 1,4-butanediol as chain extender. Nano fluor-hydroxyapatite (nFHA) was successfully synthesized by sol-gel method. The solid–liquid phase separation and solvent sublimation methods were used for preparation of the porous composites. Mechanical properties, chemical structure, and morphological characteristics of the samples were investigated by compressive test, Fourier transform infrared, and scanning electron microscopy (SEM) techniques, respectively. The effect of nFHA powder content on porosity and pore morphology was investigated. SEM images demonstrated that the scaffolds were constituted of interconnected and homogeneously distributed pores. The pore size of the scaffolds was in the range 50–250 µm. The result obtained in this research revealed that the porosity and pore average size decreased and compressive modulus increased with nFHA percentage. Considering morphological, physical, and mechanical properties, the scaffold with a higher ratio of nFHA has suitable potential use in tissue regeneration.

Keywords: polyester urethane, composite, fluor-hydroxyapatite, scaffold

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]


Other article by this author:

Manufacturing of biodegradable polyurethane scaffolds based on polycaprolactone using a phase separation method: physical properties and in vitro assay

Asefnejad A, Khorasani MT, Behnamghader A, Farsadzadeh B, Bonakdar S

International Journal of Nanomedicine 2011, 6:2375-2384

Published Date: 18 October 2011

Readers of this article also read:

Risk factors for surgical site infection in a teaching hospital: a prospective study of 1,138 patients

Cheng K, Li J, Kong Q, Wang C, Ye N, Xia G

Patient Preference and Adherence 2015, 9:1171-1177

Published Date: 14 August 2015

Cognitive and psychological profiles in treatment compliance: a study in an elderly population with hemophilia

Riva S, Nobili A, Djade CD, Mancuso ME, Santagostino E, Pravettoni G

Clinical Interventions in Aging 2015, 10:1141-1146

Published Date: 9 July 2015

Cerebrolysin effects on neurological outcomes and cerebral blood flow in acute ischemic stroke

Amiri-Nikpour MR, Nazarbaghi S, Ahmadi-Salmasi B, Mokari T, Tahamtan U, Rezaei Y

Neuropsychiatric Disease and Treatment 2014, 10:2299-2306

Published Date: 3 December 2014

Clozapine-induced seizures, electroencephalography abnormalities, and clinical responses in Japanese patients with schizophrenia

Kikuchi YS, Sato W, Ataka K, Yagisawa K, Omori Y, Kanbayashi T, Shimizu T

Neuropsychiatric Disease and Treatment 2014, 10:1973-1978

Published Date: 15 October 2014

Kynurenine and depressive symptoms in a poststroke population

Bensimon K, Herrmann N, Swardfager W, Yi H, Black SE, Gao FQ, Snaiderman A, Lanctôt KL

Neuropsychiatric Disease and Treatment 2014, 10:1827-1835

Published Date: 22 September 2014

High-sensitivity C-reactive protein, lipoprotein-related phospholipase A2, and acute ischemic stroke

Kara H, Akinci M, Degirmenci S, Bayir A, Ak A, Nayman A, Unlu A, Akyurek F, Sivri M

Neuropsychiatric Disease and Treatment 2014, 10:1451-1457

Published Date: 6 August 2014

Simple filter microchip for rapid separation of plasma and viruses from whole blood

Wang SQ, Sarenac D, Chen MH, Huang SH, Giguel FF, Kuritzkes DR, Demirci U

International Journal of Nanomedicine 2012, 7:5019-5028

Published Date: 17 September 2012