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Polypharmacy in the HIV-infected older adult population

Authors Gleason LJ, Luque AE, Shah K

Received 3 April 2013

Accepted for publication 27 April 2013

Published 21 June 2013 Volume 2013:8 Pages 749—763

DOI https://doi.org/10.2147/CIA.S37738

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Lauren J Gleason1, Amneris E Luque2, Krupa Shah1

1Division of Geriatrics and Aging, Highland Hospital, Rochester, NY, USA; 2Division of Infectious Disease, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA

Abstract: The prevalence of human immunodeficiency virus (HIV) infection among people older than 50 years is increasing. Older HIV-infected patients are particularly at risk for polypharmacy because they often have multiple comorbidities that require pharmacotherapy. Overall, there is not much known with respect to both the impact of aging on medication use in HIV-infected individuals, and the potential for interactions with highly active antiretroviral therapy (HAART) and coadministered medications and its clinical consequences. In this review, we aim to provide an overview of polypharmacy with a focus on its impact on the HIV-infected older adult population and to also provide some clinical considerations in this high-risk population.

Keywords: HIV, older adults, polypharmacy

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