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Polymorphisms in pre-miRNA genes and cooking oil fume exposure as well as their interaction on the risk of lung cancer in a Chinese nonsmoking female population

Authors Yin Z, Li H, Cui Z, Ren Y, Li X, Wu W, Guan P, Qian B, Rothman N, Lan Q, Zhou B

Received 22 September 2015

Accepted for publication 30 November 2015

Published 19 January 2016 Volume 2016:9 Pages 395—401

DOI https://doi.org/10.2147/OTT.S96870

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Manfred Beleut

Peer reviewer comments 2

Editor who approved publication: Professor Jianmin Xu


Zhihua Yin,1,2 Hang Li,1,2 Zhigang Cui,3 Yangwu Ren,1,2 Xuelian Li,1,2 Wei Wu,1,2 Peng Guan,1,2 Biyun Qian,4 Nathaniel Rothman,5 Qing Lan,5 Baosen Zhou1,2

1Department of Epidemiology, School of Public Health, China Medical University, 2Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, 3China Medical University, Shenyang, 4Department of Epidemiology, School of Public Health, Shanghai Jiao Tong University, Shanghai, People’s Republic of China; 5Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA

Background: MicroRNAs (miRNAs) are suggested to be very important in the development of lung cancer. This study assesses the association between polymorphisms in miRNA-related (miR)-26a-1, miR-605, and miR-16-1 genes and risk of lung cancer, as well as the effect of gene–environment interaction between miRNA polymorphisms and cooking fume exposure on lung cancer.
Methods: A case–control study including 268 diagnosed nonsmoking female lung cancer patients and 266 nonsmoking female controls was carried out. Three miRNA polymorphisms (miR-26a-1 rs7372209, miR-605 rs2043556, and miR-16-1 rs1022960) were analyzed. Both additive and multiplicative interactions were assessed.
Results: MiR-16-1 rs1022960 may be associated with the risk of lung cancer. Carriers with TT genotype of miR-16-1 rs1022960 were observed to have a decreased risk of lung cancer compared with CC and CT genotype carriers (odds ratio =0.550, 95% confidence interval =0.308–0.983, P=0.044). MiR-26a-1 rs7372209 and miR-605 rs2043556 showed no statistically significant associations with lung cancer risk. There were no significant associations between the three single nucleotide polymorphisms and lung adenocarcinoma. People with exposure to both risk genotypes of miR-26a-1 rs7372209 and cooking oil fumes were more likely to develop lung cancer than those with only genetic risk factor or cooking oil fumes (odds ratios were 2.136, 1.255, and 1.730, respectively). The measures of biological interaction and logistic models indicate that gene–environment interactions were not statistically significant on additive scale or multiplicative scale.
Conclusion: MiR-16-1 rs1022960 may be associated with the risk of lung cancer in a Chinese nonsmoking female population. The interactions between miRNA polymorphisms (miR-26a-1 rs7372209, miR-605 rs2043556, and miR-16-1 rs1022960) and cooking oil fumes were not statistically significant.

Keywords: lung cancer, microRNA, single nucleotide polymorphism, cooking oil fume, interaction

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