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Poly (lactic-co-glycolic acid)/graphene oxide composites combined with electrical stimulation in wound healing: preparation and characterization

Authors You D, Li K, Guo W, Zhao G, Fu C

Received 20 May 2019

Accepted for publication 9 August 2019

Published 30 August 2019 Volume 2019:14 Pages 7039—7052

DOI https://doi.org/10.2147/IJN.S216365

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Alexander Kharlamov

Peer reviewer comments 2

Editor who approved publication: Dr Linlin Sun


Di You,1 Kai Li,1 Wenlai Guo,2 Guoqing Zhao,1 Chuan Fu1

1Department of Anesthesiology, China-Japan Union Hospital of Jilin University, Changchun 130033, People’s Republic of China; 2Department of Hand and Foot Surgery, The Second Hospital of Jilin University, Changchun 130012, People’s Republic of China

Correspondence: Guoqing Zhao; Chuan Fu
Department of Anesthesiology, China-Japan Union Hospital of Jilin University, Changchun 130033, People’s Republic of China
Tel +86 1 350 088 6187; +86 1 575 430 6089
Fax +86 04 318 499 5299
Email guoqingzhao1965@163.com; fuchuan2015@163.com

Purpose: In this study, we fabricated multifunctional, electrically conductive composites by incorporating graphene oxide (GO) into a poly (lactic-co-glycolic acid) (PLGA) copolymer for wound repair. Furthermore, the resultant composites were coupled with electrical stimulation to further improve the therapeutic effect of wound repair.
Methods: We evaluated the surface morphology of the composites, as well as their physical properties, cytotoxicity, and antibacterial activity, along with the combined effects of composites and electrical stimulation (ES) in a rat model of wound healing.
Results: Application of the PLGA/GO composites to full-thickness wounds confirmed their advantageous biological properties, as evident from the observed improvements in wound-specific mechanical properties, biocompatibility, and antibacterial activity. Additionally, we found that the combination of composites and ES improved composite-mediated cell survival and accelerated wound healing in vivo by promoting neovascularization and the formation of type I collagen.
Conclusion: These results demonstrated that combined treatment with the PLGA/GO composite and ES promoted vascularization and epidermal remodeling and accelerated wound healing in rats, thereby suggesting the efficacy of PLGA/GO+ES for broad applications associated with wound repair.

Keywords: wound repair, graphene oxide, electrical stimulation, tissue engineering, PLGA


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