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POEMS syndrome complicated with multiple ischemic vascular events: case report and review of literature

Authors Găman M, Vlădăreanu AM, Dobrea C, Onisâi M, Marinescu C, Cîşleanu D, Ciufu C, Vasile D, Bumbea H, Voican I

Received 13 July 2017

Accepted for publication 9 May 2018

Published 27 September 2018 Volume 2018:11 Pages 6271—6276

DOI https://doi.org/10.2147/OTT.S146221

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Dr Faris Farassati


Mihaela Găman,1,2 Ana-Maria Vlădăreanu,1,2 Camelia Dobrea,1 Minodora Onisâi,1,2 Cristina Marinescu,1,2 Diana Cîşleanu,1,2 Cristina Ciufu,1,2 Daniela Vasile,1,2 Horia Bumbea,1,2 Irina Voican2

1Department of Hematology, University of Medicine and Pharmacy Carol Davila Bucharest, Bucharest, Romania; 2Department of Hematology, University Emergency Hospital Bucharest, Bucharest, Romania

Abstract: POEMS syndrome (acronym consisting of: polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes) is an uncommon disorder associated with an underlying plasma cell dyscrasia. There is no single specific test for POEMS, and due to its rarity and heterogeneity, patients are often mis- or underdiagnosed. Castleman disease (CD) is a rare lymphoproliferative disorder, closely related to POEMS syndrome; ~11%–30% of POEMS patients are associated with concomitant CD. In contrast to frequently published reports on vascular events in POEMS syndrome affecting coronary arteries or lower limbs, cases of cerebrovascular events are rarely mentioned in literature. We hereby report a patient with POEMS syndrome accompanied by CD who presented recurrent strokes and splenic infarction.

Keywords: POEMS, chronic inflammatory demyelinating polyradiculopathy, M protein, thrombotic risk, stroke, recurrent ischemic events

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