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Pleiotropic effects of the HMG-CoA reductase inhibitors

Authors Mihos C, Santana O

Published 4 April 2011 Volume 2011:4 Pages 261—271

DOI https://doi.org/10.2147/IJGM.S16779

Review by Single-blind

Peer reviewer comments 3

Christos G Mihos, Orlando Santana
Columbia University Division of Cardiology, Mount Sinai Heart Institute, Miami Beach, FL, USA

Abstract: The HMG-CoA reductase inhibitors (statins) are used extensively in the treatment of hyperlipidemia. They have also demonstrated a benefit in a variety of other disease processes. These secondary actions are known as pleiotropic effects. Our paper serves as a focused and updated discussion on the pleiotropy of statins and emphasizes the importance of randomized placebo-controlled trials to further elucidate this interesting phenomenon.

Keywords: HMG-CoA inhibitors, pleiotropic, reductase, review, statins

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