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Platelet-Derived Microparticles (MPs) and Thrombin Generation Velocity in Deep Vein Thrombosis (DVT): Results of a Case–Control Study

Authors Signorelli SS, Oliveri Conti G, Fiore M, Cangiano F, Zuccarello P, Gaudio A, Ferrante M

Received 27 October 2019

Accepted for publication 15 June 2020

Published 26 November 2020 Volume 2020:16 Pages 489—495

DOI https://doi.org/10.2147/VHRM.S236286

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Harry Struijker-Boudier


Salvatore Santo Signorelli,1 Gea Oliveri Conti,2 Maria Fiore,2 Federica Cangiano,2 Pietro Zuccarello,2 Agostino Gaudio,1 Margherita Ferrante2

1Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy; 2Department of Medical, Surgical Sciences and Advanced Technologies, G.F. Ingrassia, University of Catania, Catania, Italy

Correspondence: Salvatore Santo Signorelli
Department of Clinical and Experimental Medicine, University of Catania, via S.Sofia, Catania I-95123, Italy
Tel +39 0953782545
Fax +39 0953782376
Email ssignore@unict.it

Introduction: The role of platelets (Ps) and platelet-derived microparticles (MPs) in venous thromboembolism (VTE) is still being debated.
Methods: We measured MPs, velocity of thrombin formation (PiCT) and phospholipid generation (PLPs) in 40 patients with unprovoked deep vein thrombosis (DVT), who were compared with 40 healthy controls.
Results: MPs were higher in DVT (7.12 nM; 25th– 75th percentile 5.26– 9.12) than in controls (5.45 nM; 25th– 75th percentile 1.67– 8.96) (p = 0.19). PiCT velocity was lower in DVT (1.87 sec; 25th– 75th percentile 1.75– 1.93 sec) compared with controls (1.95 sec; 25th– 75th percentile 1.84– 2.24 sec) (p = 0.04). PLPs were higher in DVT (77.03 μg/mL; 25th– 75th percentile 72.12– 103.59 μg/mL) compared with controls (68.65 μg/mL, 25th– 75th percentile 55.31– 78.20 μg/mL) (p = 0.02).
Discussion: We hypothesize that MPs could be integrated with the lab network assay in evaluating Ps’ role as an activated procoagulative condition. We encourage research on Ps and P-derived microvesicle pathways in patients with unprovoked DVT and not only in patients with cancer-induced DVT.

Keywords: deep vein thrombosis, microparticles, platelet, extracellular vesicles, biomarkers

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