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Plasma Alarin Level and Its Influencing Factors in Obese Newly Diagnosed Type 2 Diabetes Patients

Authors Zhou X, Luo M, Zhou S, Cheng Z, Chen Z, Yu X

Received 2 November 2020

Accepted for publication 22 December 2020

Published 27 January 2021 Volume 2021:14 Pages 379—385

DOI https://doi.org/10.2147/DMSO.S290072

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Prof. Dr. Juei-Tang Cheng


Xin Zhou,* Mei Luo,* Sha Zhou, Zhiling Cheng, Zhongpei Chen, Xiaoxia Yu

Department of Endocrinology, Chongqing Traditional Chinese Medicine Hospital, Chongqing 400000, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Xiaoxia Yu
Department of Endocrinology, Chongqing Traditional Chinese Medicine Hospital, Chongqing 400000, People’s Republic of China
Tel/Fax +86 2363842760
Email yudoctor789@163.com

Objective: To investigate the plasma alarin level in newly diagnosed obese type 2 diabetes mellitus (T2DM) and its correlation with glucose and lipid metabolism and insulin resistance.
Methods: From October 2018 to June 2020, 239 newly diagnosed T2DM patients were collected. According to obesity, patients were divided into T2DM obese group (n=135) and T2DM non-obese group (n =104). Gender, age, body mass index (BMI), blood lipids, blood glucose, glycosylated hemoglobin A1c (HbA1c), fasting insulin (FINS), plasma alarin concentration, homeostasis model assessment for insulin resistance (HOMA-IR), homeostasis model assessment for β-cell function (HOMA-β) and other clinical data were collected and analyzed.
Results: BMI, triacylglycerol (TG), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), fasting blood glucose (FPG), HbA1c, FINS, plasma alarin levels and HOMA-IR in the control group, T2DM non-obese group and T2DM obese group increased sequentially, and high-density lipoprotein-cholesterol (HDL-L) and HOMA-β decreased sequentially (P< 0.05). Correlation analysis results showed that plasma alarin levels in T2DM patients were positively correlated with waistline, BMI, TC, LDL-C, FPG, HbA1c, FINS and HOMA-IR (P< 0.05), and negatively correlated with HDL-C and HOMA-β (P < 0.05), and the correlation coefficient of T2DM obese group was significantly higher than that of T2DM non-obese group (P< 0.05). Multiple linear stepwise regression analysis showed that BMI, FPG, HbA1c, HOMA-β, and HOMA-IR were independent factors related to plasma alarin levels in T2DM non-obese and T2DM obese patients, and the correlation coefficient of the T2DM obese group was significantly higher than that of the T2DM non-obese group (P < 0.05).
Conclusion: Plasma alarin levels increase in newly diagnosed T2DM and obese T2DM patients, which are affected by TC, BMI, FPG, HbA1c, HOMA-β and HOMA-IR, and may be involved in development of T2DM.

Keywords: type 2 diabetes mellitus, obesity, plasma alarin level, insulin resistance, blood sugar, blood lipids, insulin

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