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Plaque Fluoride Levels as a Predictor of Caries Development in Early Childhood with High Sugar Exposure – A Preliminary Study

Authors Rizzardi KF, Rodrigues LKA, Steiner-Oliveira C, Nobre-dos-Santos M, Parisotto TM

Received 12 September 2019

Accepted for publication 28 December 2019

Published 9 March 2020 Volume 2020:12 Pages 71—78


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Professor Christopher E. Okunseri

Karina Ferreira Rizzardi, 1 Lidiany Karla Azevedo Rodrigues, 2 Carolina Steiner-Oliveira, 3 Marines Nobre-dos-Santos, 3 Thaís Manzano Parisotto 1

1Laboratory of Molecular and Clinical Microbiology, University São Francisco, Bragança Paulista, SP, Brazil; 2Faculty of Pharmacy, Dentistry and Nursing, Federal University of Ceará, Fortaleza, CE, Brazil; 3Piracicaba Dental School, University of Campinas, Piracicaba, SP, Brazil

Correspondence: Thaís Manzano Parisotto
Laboratory of Molecular and Clinical Microbiology, University São Francisco, Av. São Francisco de Assis, 218, Bragança Paulista, SP 12916-900, Brazil
Tel +55 11 24548474

Objective: This longitudinal study aimed to investigate if the plaque fluoride (PF) concentration can predict the early childhood caries onset. Design: As part of a larger study, 188 preschoolers were clinically evaluated for early childhood caries diagnosis, at baseline and after 1-year follow-up. After that, the final sample comprised: 1. children who had already caries at baseline (decayed, missing or filled surfaces, as well as white chalky white spot lesions adjacent to gingival margins) and developed at least one more cavitation after one year (n=16), and 2. children who never had or developed any caries lesions, including active white spots lesions (n=15). Before the clinical examinations, dental plaque was collected. PF concentration was determined with an ion-specific electrode. A chart was used to estimate the mean daily sugar exposure. The results were statistically analyzed by Spearman correlation and logistic regression analyses (α=0.05).
Results: After one year, a positive significant correlation between caries development and liquid sucrose, total sugar and total sucrose consumption increments was found (p< 0.05). Moreover, the solid sugar, solid sucrose and total sugar exposure at baseline were positively correlated with the presence of dental plaque at follow-up (p< 0.05). To top it all, children with PF concentrations ≤ 0.1 μg/mg at baseline were 10 times more likely to develop caries.
Conclusion: In conclusion, this study demonstrated for the first time in vivo that low PF concentration is a predictor of caries development in primary teeth.

Keywords: dental caries, preschool child, fluoride, biofilm

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