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Pituitary dysfunction following traumatic brain injury: clinical perspectives

Authors Tanriverdi F, Kelestimur F

Received 21 April 2015

Accepted for publication 15 June 2015

Published 27 July 2015 Volume 2015:11 Pages 1835—1843

DOI https://doi.org/10.2147/NDT.S65814

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Xiang Mou

Peer reviewer comments 4

Editor who approved publication: Dr Roger Pinder

Fatih Tanriverdi, Fahrettin Kelestimur

Department of Endocrinology, Erciyes University Medical School, Kayseri, Turkey

Abstract: Traumatic brain injury (TBI) is a well recognized public health problem worldwide. TBI has previously been considered as a rare cause of hypopituitarism, but an increased prevalence of neuroendocrine dysfunction in patients with TBI has been reported during the last 15 years in most of the retrospective and prospective studies. Based on data in the current literature, approximately 15%–20% of TBI patients develop chronic hypopituitarism, which clearly suggests that TBI-induced hypopituitarism is frequent in contrast with previous assumptions. This review summarizes the current data on TBI-induced hypopituitarism and briefly discusses some clinical perspectives on post-traumatic anterior pituitary hormone deficiency.

Keywords: traumatic brain injury, hypopituitarism, head trauma, pituitary, growth hormone deficiency

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