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Physiological and Pathophysiological Roles of Ion Transporter-Mediated Metabolism in the Thyroid Gland and in Thyroid Cancer

Authors Wang H, Ma Z, Cheng X, Tuo B, Liu X, Li T

Received 7 September 2020

Accepted for publication 17 November 2020

Published 3 December 2020 Volume 2020:13 Pages 12427—12441

DOI https://doi.org/10.2147/OTT.S280797

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Federico Perche


Hu Wang,1 Zhiyuan Ma,1 Xiaoming Cheng,1 Biguang Tuo,2,3 Xuemei Liu,2,3 Taolang Li1

1Department of Thyroid and Breast Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, People’s Republic of China; 2Department of Gastroenterology, Affiliated Hospital of Zunyi Medical University, Zunyi, People’s Republic of China; 3Digestive Disease Institute of Guizhou Province, Zunyi, People’s Republic of China

Correspondence: Taolang Li
Department of Thyroid and Breast Surgery, Affiliated Hospital, Zunyi Medical University, Zunyi 563003, People’s Republic of China
Email [email protected]
Xuemei Liu
Department of Gastroenterology, Affiliated Hospital, Zunyi Medical University, Zunyi 563003, People’s Republic of China
Email [email protected]

Abstract: Thyroid cancer is the most common type of endocrine tumor and has shown an increasing annual incidence, especially among women. Patients with thyroid cancer have a good prognosis, with a high five-year survival rate; however, the recurrence rate and disease status of thyroid cancer remain a burden for patients, which compels us to further elucidate the pathogenesis of this disease. Recently, ion transporters have gradually become a hot topic in the field of thyroid gland biology and cancer research. Additionally, alterations in the metabolic state of tumor cells and protein molecules have gradually become the focus of scientific research. This review focuses on the progress in understanding the physiological and pathophysiological roles of ion transporter-mediated metabolism in both the thyroid gland and thyroid cancer. We also hope to shed light on new targets for the treatment and prognosis of thyroid cancer.

Keywords: thyroid cancer, metabolism, ion transporters, physiology and pathophysiology, regulation factors

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