Back to Journals » Virus Adaptation and Treatment » Volume 8

Phosphorylation of the viral coat protein regulates RNA virus infection

Authors Hoover HS, Kao CC

Received 29 July 2016

Accepted for publication 17 September 2016

Published 24 November 2016 Volume 2016:8 Pages 13—20

DOI https://doi.org/10.2147/VAAT.S118440

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Akshita Wason

Peer reviewer comments 3

Editor who approved publication: Professor Jonathan Dinman

Haley S Hoover, C Cheng Kao

Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, IN, USA

Abstract: Coat proteins (CPs) are the most abundant protein produced during a viral infection. CPs have been shown to regulate the infection processes of RNA viruses, including RNA replication and gene expression. The numerous activities of the CP in infection are likely to require regulation, possibly through posttranslational modifications. Protein posttranslational modifications are involved in signal transduction, expanding and regulating protein function, and responding to changes in the environment. Accumulating evidence suggests that phosphorylation of viral CPs is involved in the regulation of the viral infection process from enabling virion disassembly to regulation of viral protein synthesis and replication. CP phosphorylation also affects viral trafficking and virion assembly. This review focuses on the regulatory roles that phosphorylation of CPs has in the life cycle of viruses with RNA genomes.

Keywords: viral capsid protein, posttranslational modification, phosphorylation, protein–RNA interaction

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]

 

Other articles by this author:

Mapping protein–RNA interactions

Vaughan R, Running W, Qi R, Kao CC

Virus Adaptation and Treatment 2012, 4:29-41

Published Date: 2 May 2012

Small molecule inhibitors of the SARS-CoV Nsp15 endoribonuclease

J Ortiz-Alcantara, K Bhardwaj, S Palaninathan, et al.

Virus Adaptation and Treatment 2010, 2:125-133

Published Date: 6 September 2010

Conformations of the monomeric hepatitis C virus RNA-dependent RNA polymerase

Sreedhar Chinnaswamy, Ayaluru Murali, Hui Cai, et al

Virus Adaptation and Treatment 2010, 2:21-39

Published Date: 11 March 2010