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Phosphorylation at endothelial cell–cell junctions: Implications for VE-cadherin function

Authors Timmerman I, Hordijk P, Van Buul J

Published 17 May 2010 Volume 2010:2 Pages 23—31

DOI https://doi.org/10.2147/CHC.S9590

Review by Single-blind

Peer reviewer comments 7


Ilse Timmerman, Peter L Hordijk, Jaap D van Buul

Department of Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, The Netherlands

Abstract: Endothelial cell–cell junctions are strictly regulated in order to control the barrier function of endothelium. Vascular endothelial (VE)-cadherin is one of the proteins that is crucial in this process. It has been reported that phosphorylation events control the function of VE-cadherin. This review summarizes the role of VE-cadherin phosphorylation in the regulation of endothelial cell–cell junctions and highlights how this affects vascular permeability and leukocyte extravasation.
Keywords: endothelium, VE-cadherin, junctions, barrier, phosphorylation

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