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PHD2: from hypoxia regulation to disease progression

Authors Meneses A, Wielockx B

Received 21 January 2016

Accepted for publication 18 February 2016

Published 11 April 2016 Volume 2016:4 Pages 53—67

DOI https://doi.org/10.2147/HP.S53576

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Thomas Kietzmann

Peer reviewer comments 2

Editor who approved publication: Prof. Dr. Roland Wenger


Ana M Meneses, Ben Wielockx

Heisenberg Research Group, Department of Clinical Pathobiochemistry, Institute for Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, Dresden, Germany

Abstract: Oxygen represents one of the major molecules required for the development and maintenance of life. An adequate response to hypoxia is therefore required for the functioning of the majority of living organisms and relies on the activation of the hypoxia-inducible factor (HIF) pathway. HIF prolyl hydroxylase domain-2 (PHD2) has long been recognized as the major regulator of this response, controlling a myriad of outcomes that range from cell death to proliferation. However, this enzyme has been associated with more pathways, making the role of this protein remarkably complex under distinct pathologies. While a protective role seems to exist in physiological conditions such as erythropoiesis; the picture is more complex during pathologies such as cancer. Since the regulation of this enzyme and its closest family members is currently considered as a possible therapy for various diseases, understanding the different particular roles of this protein is essential.

Keywords: Hypoxia, PHD, HIF, inflammation, cancer

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