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Pharmacology and clinical potential of oblimersen sodium in the treatment of chronic lymphocytic leukemia

Authors Borthakur G, O'Brien S

Received 27 March 2012

Accepted for publication 25 May 2012

Published 20 August 2012 Volume 2012:2 Pages 137—143

DOI https://doi.org/10.2147/BLCTT.S23260

Review by Single anonymous peer review

Peer reviewer comments 4



Gautam Borthakur, Susan O'Brien

Department of Leukemia, MD Anderson Cancer Center, Houston, TX, USA

Abstract: Targeted inhibition of the Bcl-2 family of antiapoptotic proteins is expected to improve outcomes in chronic lymphocytic leukemia. Antisense oligonucleotides and small molecule inhibitors (BH3 mimetics) are two approaches that have been used to target Bcl-2 proteins. In this review, we summarize the experience with oblimersen sodium, an 18-base oligonucleotide targeting the first six codons of Bcl-2 mRNA, with particular focus on chronic lymphocytic leukemia. Despite evidence of improved outcomes in randomized trials of combination with chemoimmunotherapy, further development of this antisense approach has been slow, likely because of the clinical development of small molecule inhibitors.

Keywords: oblimersen, Bcl-2, antisense, chronic lymphocytic leukemia

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