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Pharmacogenomics of sickle cell disease: steps toward personalized medicine

Authors Husain M, Hartman AD, Desai P

Received 10 June 2017

Accepted for publication 9 August 2017

Published 19 October 2017 Volume 2017:10 Pages 261—265

DOI https://doi.org/10.2147/PGPM.S123427

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Akshita Wason

Peer reviewer comments 2

Editor who approved publication: Dr Martin Bluth


Marium Husain,1 Amber D Hartman,2 Payal Desai3

1Division of Medical Oncology, 2Division of Palliative Medicine, 3Division of Hematology, The Ohio State University Wexner Medical Center, Columbus, OH, USA

Abstract: Sickle cell disease (SCD) is a monogenetic disease but has a wide range of phenotypic expressions. Some of these differences in phenotype can be explained by genetic polymorphisms in the human globin gene. These polymorphisms can result in different responses to typical treatment, sometimes leading to inadequate therapeutics. Research is revealing more polymorphisms, and therefore, new targets for intervention to improve outcomes in SCD. This area of pharmacogenomics is continuing to develop. We provide a brief review of the current literature on pharmacogenomics in SCD and possible targets for intervention.

Keywords: sickle cell disease, pharmacogenomics, hydroxyurea, opioids, HbF inducers, gene therapy

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