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Phage therapy as a renewed therapeutic approach to mycobacterial infections: a comprehensive review

Authors Azimi T, Mosadegh M, Nasiri MJ, Sabour S, Karimaei S, Nasser A

Received 7 June 2019

Accepted for publication 31 August 2019

Published 17 September 2019 Volume 2019:12 Pages 2943—2959

DOI https://doi.org/10.2147/IDR.S218638

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Melinda Thomas

Peer reviewer comments 2

Editor who approved publication: Dr Joachim Wink


Taher Azimi,1,2 Mehrdad Mosadegh,2 Mohammad Javad Nasiri,1 Sahar Sabour,3 Samira Karimaei,2 Ahmad Nasser4

1Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran; 3Department of Microbiology, School of Medicine, Ardabil University of Medical Science, Ardabil, Iran; 4Clinical Microbiology Research Center, Ilam University of Medical Science, Ilam, Iran

Correspondence: Taher Azimi
Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, PO Box 15468-15514, Tehran, Iran
Tel +98 938 213 0411
Email Taherazimi5@gmail.com

Abstract: Mycobacterial infections are considered to a serious challenge of medicine, and the emergence of MDR and XDR tuberculosis is a serious public health problem. Tuberculosis can cause high morbidity and mortality around the world, particularly in developing countries. The emergence of drug-resistant Mycobacterium infection following limited therapeutic technologies coupled with the serious worldwide tuberculosis epidemic has adversely affected control programs, thus necessitating the study of the role bacteriophages in the treatment of mycobacterial infection. Bacteriophages are viruses that are isolated from several ecological specimens and do not exert adverse effects on patients. Phage therapy can be considered as a significant alternative to antibiotics for treating MDR and XDR mycobacterial infections. The useful ability of bacteriophages to kill Mycobacterium spp has been explored by numerous research studies that have attempted to investigate the phage therapy as a novel therapeutic/diagnosis approach to mycobacterial infections. However, there are restricted data about phage therapy for treating mycobacterial infections. This review presents comprehensive data about phage therapy in the treatment of mycobacterial infection, specifically tuberculosis disease.

Keywords: mycobacteriophage, tuberculosis, mycobacteria infection, phage therapy


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