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pH-responsive glycol chitosan-cross-linked carboxymethyl-β-cyclodextrin nanoparticles for controlled release of anticancer drugs

Authors Wang Y, Qin F, Tan H, Zhang Y, Jiang M, Lu M, Yao X

Received 7 July 2015

Accepted for publication 2 October 2015

Published 8 December 2015 Volume 2015:10(1) Pages 7359—7370

DOI https://doi.org/10.2147/IJN.S91906

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Govarthanan Muthusamy

Peer reviewer comments 2

Editor who approved publication: Dr Lei Yang

Yiwen Wang,* Fei Qin,* Haina Tan, Yan Zhang, Miao Jiang, Mei Lu, Xin Yao

School of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences, Beijing, People’s Republic of China

*These authors contributed equally to this work

Abstract: Carboxymethyl-β-cyclodextrin (CMβ-CD)-modified glycol chitosan (GCS) nanoparticles (GCS-CMβ-CD NPs) were synthesized, and their pH-sensitive drug-release properties were investigated. GCS-CMβ-CD NPs could encapsulate doxorubicin hydrochloride (DOX), and the encapsulation efficiency and loading capacity increased with the amount of CMβ-CD. Drug-release studies indicate that DOX released was greater in acidic medium (pH 5.0) than in weakly basic medium (pH 7.4). The mechanism underlying the pH-sensitive properties of the carrier was analyzed. Finally, the MCF-7 (human breast cancer) and SW480 cell lines (human colon cancer) were used to evaluate the cytotoxicity of the NPs. The drug-loaded carriers show good inhibition of the growth of cancer cells compared with free DOX, and the carriers have good biocompatibility. In addition, the drug-loaded NPs have sustained drug-release properties. All these properties of the newly synthesized GCS-CMβ-CD NPs suggest a promising potential as an effective anticancer drug-delivery system for controlled drug release.

Keywords: MCF-7, SW480, surface plasmon resonance, encapsulation efficiency, loading capacity, cell viability

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