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PET imaging using radiolabelled antibodies: future direction in tumor diagnosis and correlate applications

Authors Salsano M, Treglia G

Received 29 April 2013

Accepted for publication 27 June 2013

Published 31 July 2013 Volume 2013:3 Pages 9—17


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Marco Salsano,1 Giorgio Treglia2

1Department of Radiology, Catholic University of Rome, Rome, Italy; 2Department of Nuclear Medicine, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland

Abstract: Immuno-positron emission tomography (PET) is a new imaging tool that finds application in diagnostic as well as in prognostic and therapeutic oncology. Monoclonal antibodies (mAbs) present the unique ability to selectively bind specific antigens produced by tumors, establishing the presence, location, and number of neoplastic foci. They are produced in unlimited quantities with absolute specificity using the hybridoma method. Treatment with mAbs can have different forms: they can be administered alone or can be combined with a radioactive molecule, which then delivers the radiation directly to the tumor cells. In immuno-PET, mAbs are labeled with various radionuclides and used in cancer patients who produce tumor-associated antigens. In this review we will discuss immuno-PET applications in tumor diseases, focusing on the technique, mAbs, positron emitter selection, and on its future applications.

Keywords: Immuno-PET, monoclonal antibodies, radionuclides, radiolabeling

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