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Pertuzumab in human epidermal growth-factor receptor 2-positive breast cancer: clinical and economic considerations

Authors Lamond N, Younis T

Received 5 December 2013

Accepted for publication 4 February 2014

Published 16 May 2014 Volume 2014:6 Pages 509—521

DOI https://doi.org/10.2147/IJWH.S47357

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3


Nathan WD Lamond, Tallal Younis

Department of Medicine, Dalhousie University at the Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada

Abstract: In the absence of specific therapy, the 15%–20% of breast cancers demonstrating human epidermal growth-factor receptor 2 (HER2) protein overexpression and/or gene amplification are characterized by a more aggressive phenotype and poorer prognosis compared to their HER2-negative counterparts. Trastuzumab (Herceptin), the first anti-HER2-targeted therapy, has been associated with improved survival outcomes in HER2-positive breast cancer. However, many patients with early stage disease continue to relapse, and metastatic disease remains incurable. In order to further improve these outcomes, several novel HER2-targeted agents have recently been developed. Pertuzumab (Perjeta), a monoclonal antibody against the HER2 dimerization domain, has also been associated with improved patient outcomes in clinical trials, and has recently been approved in combination with chemotherapy and trastuzumab for neoadjuvant therapy of early stage, HER2-positive breast cancer and first-line treatment of metastatic disease. This review briefly summarizes pertuzumab's clinical development as well as the published evidence supporting its use, and highlights some of the currently unanswered questions that will influence pertuzumab’s incorporation into clinical practice.

Keywords: HER2/neu, clinical trials, drug development, novel therapies, targeted anticancer therapy

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