Peripherally inserted central catheter thrombosis incidence and risk factors in cancer patients: a double-center prospective investigation
Authors Liu Y, Gao Y, Wei L, Chen W, Ma X, Song L
Received 28 August 2014
Accepted for publication 24 November 2014
Published 29 January 2015 Volume 2015:11 Pages 153—160
Checked for plagiarism Yes
Review by Single-blind
Peer reviewer comments 3
Editor who approved publication: Professor Garry Walsh
Yuxiu Liu,1 Yufang Gao,3 Lili Wei,3 Weifen Chen,1 Xiaoyan Ma,4 Lei Song2
1Oncology Department, The Affiliated Hospital of Qingdao University, Qingdao, People’s Republic of China; 2Department of Breast Oncology, The Affiliated Hospital of Qingdao University, Qingdao, People’s Republic of China; 3Nursing Department, The Affiliated Hospital of Qingdao University, Qingdao, People’s Republic of China; 4Intensive Care Unit, Shanghai East Hospital, Shanghai, People’s Republic of China
Background: Peripherally inserted central catheters (PICCs) are widely used in chemotherapy, but the reported PICC thrombosis incidence varies greatly, and risks of PICC thrombosis are not well defined. This study was to investigate the incidence and risk factors of PICC-related upper extremity vein thrombosis in cancer patients.
Methods: This was a prospective study conducted in two tertiary referral hospitals from May 2010 to February 2013. Cancer patients who were subject to PICC placement were enrolled and checked by Doppler ultrasound weekly for at least 1 month. Univariable and multivariable logistic regression analyses were applied for identification of risk factors.
Results: Three hundred and eleven cancer patients were enrolled in the study. One hundred and sixty (51.4%) developed PICC thrombosis, of which 87 (54.4%) cases were symptomatic. The mean time interval from PICC insertion to thrombosis onset was 11.04±5.538 days. The univariable logistic regression analysis showed that complications (odds ratio [OR] 1.686, P=0.032), less activity (OR 1.476, P=0.006), obesity (OR 3.148, P=0.000), and chemotherapy history (OR 3.405, P=0.030) were associated with PICC thrombosis. Multivariate analysis showed that less activity (OR 9.583, P=0.000) and obesity (OR 3.466, P=0.014) were significantly associated with PICC thrombosis.
Conclusions: The incidence of PICC thrombosis is relatively high, and nearly half are asymptomatic. Less activity and obesity are risk factors of PICC-related thrombosis.
Keywords: PICC, complication, clinical study, catheter-related thrombosis, upper extremity vein thrombosis
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