Back to Journals » Vascular Health and Risk Management » Volume 4 » Issue 1

Perioperative use of statins in noncardiac surgery

Authors Chan YC, Cheng SW, Irwin MG

Published 8 February 2008 Volume 2008:4(1) Pages 75—81

DOI https://doi.org/10.2147/VHRM.S1915


YC Chan1, SW Cheng1, MG Irwin2

1Division of Vascular Surgery and 2Anaesthesiology, University of Hong Kong Medical Centre, South Wing, 14th Floor K Block, Queen Mary Hospital, Hong Kong, China

Background: Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) can significantly decrease cardiovascular mortality and morbidity, irrespective of the patients’ cholesterol status. This paper reviews the effects of perioperative statin therapy in patients undergoing noncardiac surgery.

Method: A systematic literature review was undertaken of all published literature on this subject using Medline and cross-referenced. All published relevant papers on the perioperative use of statins were used.

Results: Perioperative statin therapy is associated with a lower perioperative morbidity and mortality in patients undergoing elective or emergency surgery. The effects are due to a combination of lipid-lowering and pleiotropic properties of statins.

Conclusion: Ideally a large scale multi-centre randomized controlled trial of perioperative statin therapy should be performed but this may be difficult to conduct since there is already overwhelming evidence in the literature to suggest perioperative cardiovascular protective properties. Statins may still be under-prescribed in surgical patients.

Keywords: perioperative, cardiac complications, morbidity, mortality, outcome, statins, vascular, noncardiac surgery

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]