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Perindopril for improving cardiovascular events

Authors DiNicolantonio J, O'Keefe J

Received 25 May 2014

Accepted for publication 30 June 2014

Published 30 August 2014 Volume 2014:10 Pages 539—548

DOI https://doi.org/10.2147/VHRM.S68384

Checked for plagiarism Yes


James J DiNicolantonio, James H O'Keefe

Department of Preventive Cardiology, Saint Luke's Mid America Heart Institute, Kansas City, MO, USA

In a recent review in Vascular Health and Risk Management Wang et al state that “In mainly placebo-controlled cardiovascular (CV)-outcome studies in patients with hypertension, CV benefits with perindopril were associated with large reductions in BP.”1 However, perindopril in the European Trial on Reduction of Cardiac Events With Perindopril in Stable Coronary Artery Disease (EUROPA) study significantly reduced major cardiovascular events despite a small reduction (approximately 4 mmHg) in systolic blood pressure from baseline.2,3 Additionally, the average baseline blood pressure in the EUROPA was just 137/82 mmHg, and in those without hypertension, perindopril still provided a 20% reduction in the combined endpoint of cardiovascular death, myocardial infarction, and cardiac arrest.4,5 In fact, patients receiving perindopril with a baseline systolic blood pressure of <120 mmHg had the greatest reduction in the primary event.

View original paper by Wang and colleagues.
 

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