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Perceptions and attitudes toward clinical trials in adolescent and young adults with cancer: a systematic review

Authors Forcina V, Vakeesan B, Paulo CB, Mitchell L, Bell JAH, Tam S, Wang K, Gupta AA, Lewin J

Received 19 January 2018

Accepted for publication 28 March 2018

Published 13 June 2018 Volume 2018:9 Pages 87—94

DOI https://doi.org/10.2147/AHMT.S163121

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Ms Justinn Cochran

Peer reviewer comments 2

Editor who approved publication: Professor Alastair Sutcliffe


Victoria Forcina,1 Branavan Vakeesan,1 Chelsea Paulo,1 Laura Mitchell,1 Jennifer AH Bell,2 Seline Tam,1 Kate Wang,1 Abha A Gupta,1,3,4 Jeremy Lewin1,3,5

1Adolescent and Young Adult Program, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada; 2Joint Center for Bioethics, University of Toronto, Toronto, ON, Canada; 3Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada; 4Division of Hematology/Oncology, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada; 5ONTrac, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia

Purpose: Although cancer clinical trials (CT) offer opportunities for novel treatments that may lead to improved outcomes, adolescents and young adults (AYA) are less likely to participate in these trials as compared to younger children and older adults. We aimed to identify the perceptions and attitudes toward CT in AYA that influence trial participation.
Materials and methods: A systematic review of cancer literature was conducted that assessed perceptions and attitudes toward CT enrollment limited to AYA patients (defined as age 15–39). We estimated the frequency of identified themes by pooling identified studies.
Results: In total, six original research articles were identified that specifically addressed perceptions or attitudes that influenced CT participation in AYA patients. Three studies were conducted at pediatric centers – one at an AYA unit, one at an adult cancer hospital, and one was registry based. Major themes identified for CT acceptability included: hope for positive clinical affect, altruism, and having autonomy. Potential deterrents included: prolonged hospitalization, worry of side effects, and discomfort with experimentation.
Conclusion: Limited information is available with regard to the perceptions and attitudes toward CT acceptability among AYA patients, especially those treated at adult cancer centers, which prevents generalization of data and themes. Future research assessing strategies for understanding and supporting CT decision-making processes among AYA represents a key focus for future funding to improve CT enrollment.

Keywords: adolescent and young adult, clinical trials, barriers, psychosocial, cancer

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