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Pelvic lymph node dissection in the context of radical cystectomy: a thorough insight into the connection between patient, surgeon, pathologist and treating institution

Authors Seiler R, Thalmann, Zehnder P

Received 4 April 2013

Accepted for publication 28 May 2013

Published 12 August 2013 Volume 2013:5 Pages 121—128

DOI https://doi.org/10.2147/RRU.S32333

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 6


Roland Seiler, George N Thalmann, Pascal Zehnder

Department of Urology, University of Bern, Bern, Switzerland

Abstract: Pelvic lymph node dissection (PLND) in patients with bladder cancer varies widely in extent, technique employed, and pathological workup of specimens. The present paper provides an overview of the existing evidence regarding the effectiveness of PLND and elucidates the interactions between patient, surgeon, pathologist, and treating institution as well as their cumulative impact on the final postoperative lymph node (LN) staging. Bladder cancer patients undergoing radical cystectomy with extended PLND appear to have better oncologic outcomes compared to patients undergoing radical cystectomy and limited PLND. Attempts have been made to define and assess the quality of PLND according to the number of lymph nodes identified. However, lymph node counts depend on multiple factors such as patient characteristics, surgical template, pathological workup, and institutional policies; hence, meticulous PLND within a defined and uniformly applied extended template appears to be a better assurance of quality than absolute lymph node counts. Nevertheless, the prognosis of the patients can be partially predicted with findings from the histopathological evaluation of the PLND specimen, such as the number of positive lymph nodes, extracapsular extension, and size of the largest LN metastases. Therefore, particular prognostic parameters should be addressed within the pathological report to guide the urologist in terms of patient counseling.

Keywords: bladder cancer, outcome, pathological workup, postoperative staging

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