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Pediatric papillary thyroid cancer: current management challenges

Authors Verburg FA, Van Santen HM, Luster M

Received 8 September 2016

Accepted for publication 11 November 2016

Published 28 December 2016 Volume 2017:10 Pages 165—175

DOI https://doi.org/10.2147/OTT.S100512

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Ashok Kumar Pandurangan

Peer reviewer comments 2

Editor who approved publication: Dr Yao Dai

Frederik A Verburg,1 Hanneke M Van Santen,2 Markus Luster1

1University Hospital GieΒen and Marburg, Department of Nuclear Medicine, Marburg, Germany; 2University Medical Center Utrecht, Wilhelmina Children’s Hospital, Utrecht, the Netherlands

Abstract: Although with a standardized incidence of 0.54 cases per 100,000 persons, differentiated thyroid cancer (DTC) is a rare disease in children and adolescents, it nonetheless concerns ~1.4% of all pediatric malignancies. Furthermore, its incidence is rising. Due to the rarity and long survival of pediatric DTC patients, in most areas of treatment little evidence exists. Treatment of pediatric DTC is therefore littered with controversies, many questions therefore remain open regarding the optimal management of pediatric papillary thyroid cancer (PTC), and many challenges remain unsolved. In the present review, we aim to provide an overview of these challenging areas of patient and disease management in pediatric PTC patients. Data on diagnosis, surgery, radionuclide, and endocrine therapy are discussed, and the controversies therein are highlighted.

Keywords:
pediatric cancer, papillary thyroid cancer, survival, I-131 therapy, follow-up, treatment

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