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PD-1/PD-L1 blockades in non-small-cell lung cancer therapy

Authors Kong L, Li M, Zhang Y, Teng F, Han A, Kong L, Zhu H

Received 23 August 2015

Accepted for publication 23 November 2015

Published 25 January 2016 Volume 2016:9 Pages 489—502

DOI https://doi.org/10.2147/OTT.S94993

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Jia Fan

Peer reviewer comments 3

Editor who approved publication: Dr Faris Farassati


Wang Jing,1,2,* Miaomiao Li,3,* Yan Zhang,2 Feifei Teng,2 Anqin Han,2 Li Kong,2 Hui Zhu2

1Weifang Medical University, Weifang, Shandong Province, People’s Republic of China; 2Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Jinan, Shandong Province, People’s Republic of China; 3Shandong Medical College, Jinan, Shandong Province, People’s Republic of China

*Both these authors contributed equally to the work

Abstract: Lung cancer is the leading cause of cancer death in males and the second leading cause of death in females worldwide. Non-small-cell lung cancer (NSCLC) is the main pathological type of lung cancer, and most newly diagnosed NSCLC patients cannot undergo surgery because the disease is already locally advanced or metastatic. Despite chemoradiotherapy and targeted therapy improving clinical outcomes, overall survival remains poor. Immune checkpoint blockade, especially blockade of programmed death-1 (PD-1) receptor and its ligand PD-L1, achieved robust responses and improved survival for patients with locally advanced/metastatic NSCLC in preclinical and clinical studies. However, with regard to PD-1/PD-L1 checkpoint blockade as monotherapy or in combination with other antitumor therapies, such as chemotherapy, radiotherapy (including conventional irradiation and stereotactic body radiotherapy), and target therapy, there are still many unknowns in treating patients with NSCLC. Despite this limited understanding, checkpoint blockade as a novel therapeutic approach may change the treatment paradigm of NSCLC in the future. Here we review the main results from completed and ongoing studies to investigate the feasibility of PD-1/PD-L1 inhibitors, as monotherapy or combinatorial agents in patients with locally advanced and metastatic NSCLC, and explore optimal strategy in such patients.

Keywords: immunotherapy, checkpoint, PD-1, PD-L1, NSCLC

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