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Patient experience and practice trends in multiple sclerosis – clinical utility of fingolimod

Authors Lee J, Han M

Received 29 January 2015

Accepted for publication 4 April 2015

Published 21 May 2015 Volume 2015:9 Pages 685—693


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 6

Editor who approved publication: Dr Johnny Chen

Jong-Mi Lee,1 May H Han1,2

1Stanford Healthcare, Multiple Sclerosis Center, 2Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford University, Stanford, CA, USA

Abstract: Targeting sphingosine-1-phosphate pathway with orally available immune-modulatory fingolimod (Gilenya™) therapy ameliorates relapsing–remitting multiple sclerosis (RRMS) by decreasing relapse rate as shown in FREEDOMS and TRANSFORMS. Fingolimod has also been shown to be superior to interferon-beta therapy as evidenced by TRANSFORMS. Albeit multiple benefits in treatment of multiple sclerosis including high efficacy and ease of administration, potential untoward effects such as cardiotoxicity, risk of infection, and cancer exist, thus mandating careful screening and frequent monitoring of patients undergoing treatment with fingolimod. This review outlines mechanism of action, observations, side effects, and practice guidelines on use of fingolimod in treatment of RRMS.

Keywords: sphingosine-1-phosphate, RRMS, FREEDOMS, TRANSFORMS, side effects, IFNβ

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