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Pathogenesis of coronary artery disease: focus on genetic risk factors and identification of genetic variants

Authors Sayols-Baixeras S, Lluís-Ganella C, Lucas G, Elosua R

Received 2 October 2013

Accepted for publication 2 November 2013

Published 16 January 2014 Volume 2014:7 Pages 15—32

DOI https://doi.org/10.2147/TACG.S35301

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2


Sergi Sayols-Baixeras, Carla Lluís-Ganella, Gavin Lucas, Roberto Elosua

Cardiovascular Epidemiology and Genetics Research Group, Institut Hospital del Mar d'Investigacions Mèdiques, Barcelona, Spain

Abstract: Coronary artery disease (CAD) is the leading cause of death and disability worldwide, and its prevalence is expected to increase in the coming years. CAD events are caused by the interplay of genetic and environmental factors, the effects of which are mainly mediated through cardiovascular risk factors. The techniques used to study the genetic basis of these diseases have evolved from linkage studies to candidate gene studies and genome-wide association studies. Linkage studies have been able to identify genetic variants associated with monogenic diseases, whereas genome-wide association studies have been more successful in determining genetic variants associated with complex diseases. Currently, genome-wide association studies have identified approximately 40 loci that explain 6% of the heritability of CAD. The application of this knowledge to clinical practice is challenging, but can be achieved using various strategies, such as genetic variants to identify new therapeutic targets, personal genetic information to improve disease risk prediction, and pharmacogenomics. The main aim of this narrative review is to provide a general overview of our current understanding of the genetics of coronary artery disease and its potential clinical utility.

Keywords: coronary artery disease, pathogenesis, genetic risk factors, genetic variants

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