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Passive targeting of ischemic-reperfused myocardium with adenosine-loaded silica nanoparticles

Authors Galagudza M, Korolev D, Postnov V, Naumisheva E, Grigorova Y, Uskov I, Shlyakhto E

Received 26 December 2011

Accepted for publication 11 February 2012

Published 13 April 2012 Volume 2012:7 Pages 1671—1678

DOI https://doi.org/10.2147/IJN.S29511

Review by Single-blind

Peer reviewer comments 3

Michael Galagudza1, Dmitry Korolev1, Viktor Postnov2, Elena Naumisheva2, Yulia Grigorova3, Ivan Uskov1, Eugene Shlyakhto1
1Institute of Experimental Medicine, VA Almazov Federal Heart, Blood and Endocrinology Center, 2Chemical Faculty, St Petersburg State University, 3Department of Pathophysiology, IP Pavlov State Medical University, St Petersburg, Russian Federation

Abstract: Pharmacological agents suggested for infarct size limitation have serious side effects when used at cardioprotective doses which hinders their translation into clinical practice. The solution to the problem might be direct delivery of cardioprotective drugs into ischemic-reperfused myocardium. In this study, we explored the potential of silica nanoparticles for passive delivery of adenosine, a prototype cardioprotective agent, into ischemic-reperfused heart tissue. In addition, the biodegradation of silica nanoparticles was studied both in vitro and in vivo. Immobilization of adenosine on the surface of silica nanoparticles resulted in enhancement of adenosine-mediated infarct size limitation in the rat model. Furthermore, the hypotensive effect of adenosine was attenuated after its adsorption on silica nanoparticles. We conclude that silica nanoparticles are biocompatible materials that might potentially be used as carriers for heart-targeted drug delivery.

Keywords: silica nanoparticles, targeted drug delivery, myocardium, ischemia, reperfusion

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